Spatial learning in rats is impaired after degeneration of the nigrostriatal dopaminergic system
Spatial learning in rats is impaired after degeneration of the nigrostriatal dopaminergic system
复制标题
黑质纹状体多巴胺能系统退化后大鼠的空间学习受损
DOI：
10.1002/mds.10472
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发表时间：
2003
影响因子：
8.6
通讯作者：
J. Feldon,
中科院分区：
文献类型：
--
作者：
A. Mura;J. Feldon,
我们研究了单侧和双侧黑质纹状体多巴胺能系统损伤大鼠的空间学习能力。我们使用了Morris水迷宫范式，该范式测试了学习和记忆的空间形式，并允许区分感觉运动和学习障碍。术前训练动物学习空间固定的隐藏平台的位置，以便从游泳池逃生（习得训练）。在习得训练前后分别进行视觉测试和探针测试。我们的研究结果表明，单侧损伤的动物虽然表现出较长的逃避潜伏期，但具有正常的空间记忆能力。双侧损伤的动物能游得和单侧损伤的动物一样快，甚至更快。尽管这些动物在术前已经学会了空间导航任务，但双侧多巴胺能损伤导致在获取任务中发现隐藏平台的能力严重不足。一般来说，双侧病变的动物坚持沿着池壁游泳，在探针测试中它们的空间导航性能非常差。这些结果表明，黑质纹状体多巴胺能系统的缺陷可以影响空间导航行为策略的选择和维持。©2003运动障碍学会
We investigated spatial learning in rats with unilateral and bilateral lesions of the nigrostriatal dopaminergic system. We used the Morris water maze paradigm, which tests spatial forms of learning and memory and allows discrimination between sensory‐motor and learning disabilities. Animals were trained preoperatively to learn the location of a spatially fixed hidden platform to escape from the swimming pool (acquisition training). A visual and a probe test were used before and after the acquisition training, respectively. Our results show that animals with unilateral lesions, although displaying longer escape latencies, have normal spatial memory abilities. Animals with bilateral lesions were able to swim as fast or even faster than animals with unilateral lesion. Despite the fact that these animals had learned the spatial navigation tasks preoperatively, bilateral dopaminergic lesions led to a profound deficit in ability to find a hidden platform during an acquisition task. In general, animals with bilateral lesions persisted in swimming along the pool walls and their spatial navigation performance during a probe test was very poor. These results suggest that deficit of the nigrostriatal dopaminergic system can affect the selection and maintenance of behavioral strategies in spatial navigation. © 2003 Movement Disorder Society
影响因子：
--
作者：
KEEFE, KA;SALAMONE, JD;STRICKER, EM
通讯作者：
STRICKER, EM