The regulation of radiosensitivity by p53 and its acetylation.
The regulation of radiosensitivity by p53 and its acetylation.
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DOI：
10.1016/j.canlet.2015.04.015
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发表时间：
2015-07
期刊：
影响因子：
9.7
通讯作者：
Jing Zhang;Liangfang Shen;Lunquan Sun
中科院分区：
文献类型：
--
作者：
Jing Zhang;Liangfang Shen;Lunquan Sun
p53信号通路在决定正常组织的放射敏感性方面起着关键作用，但在癌症中经常失活。在各种癌细胞中，p53通过复杂的机制对放射敏感性产生不同的影响。p53的乙酰化是翻译后修饰的重要手段，并且对于其可逆的酶促活化过程是必不可少的。p53的乙酰化和去乙酰化都参与了细胞对DNA损伤和遗传毒性应激（如辐射）反应的精细调节。靶向p53的乙酰化可以调节癌细胞的放射敏感性。
The p53 signaling pathway plays critical roles in determining the radio-sensitivity of normal tissues but is frequently inactivated in cancer. In various cancer cells, p53 has different effects on radio-sensitivity through complex mechanisms. Acetylation of p53 is an important means of post-translational modifications and is indispensable for its activation that is a reversible enzymatic process. Both acetylation and deacetylation of p53 are involved in the fine regulation of cellular responses to DNA damage and genotoxic stress, such as radiation. Targeting the acetylation of p53 may enable the modulation of radio-sensitivity of cancer cells.