Effectiveness of 5-Aminolevulinic Acid Photodynamic Therapy in the Treatment of Hidradenitis Suppurativa: A Report of 5 Cases
Effectiveness of 5-Aminolevulinic Acid Photodynamic Therapy in the Treatment of Hidradenitis Suppurativa: A Report of 5 Cases
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DOI：
10.1016/j.ad.2013.10.016
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发表时间：
2014-07-01
影响因子：
3.2
通讯作者：
Parra Cares, J.
中科院分区：
文献类型：
--
作者：
Andino Navarrete, R.;Hasson Nisis, A.;Parra Cares, J.
化脓性汗腺炎是一种累及整个毛囊的慢性、复发性和致残性炎症性疾病。包括光动力疗法在内的几种治疗方法已被使用，但结果不一致且复发率高。在这项前瞻性研究中，我们评估了5例中至重度化脓性汗腺炎患者的病情严重程度、生活质量和治疗耐受性。治疗效果通过缝匠肌严重度评分、皮肤科生活质量指数、疼痛和疾病活动度的视觉模拟评分进行评估。3种仪器均有显著改善，8周后仍可见效果。我们的结果表明，用5-氨基乙酰丙酸和635 nm的光波长进行光动力治疗可以减轻难治性化脓性汗腺炎患者的病情，提高患者的生活质量。(C)2013年埃尔塞维尔·埃斯帕纳、S.L.和AEDV。版权所有。
Hidradenitis suppurativa has been described as a chronic, recurrent, and disabling inflammatory disease involving the entire hair follicle.Several treatments, including photodynamic therapy, have been used, but the results have been inconsistent and recurrence is high.In this prospective study, we evaluated disease severity, quality of life, and treatment tolerance in 5 patients with moderate to severe hidradenitis suppurativa treated with photodynamic therapy using 5-aminolevulinic acid and a 635-nm light source. Treatment effectiveness was evaluated using the Sartorius severity score, the Dermatology Life Quality Index, and a visual analog scale for pain and disease activity.Significant improvements were observed with all 3 instruments and the effects remained visible at 8 weeks. Our results suggest that photodynamic therapy with 5-aminolevulinic acid and a light wavelength of 635 nm could reduce disease severity and improve quality of life in patients with difficult-to-treat hidradenitis suppurativa. (C) 2013 Elsevier Espana, S.L. and AEDV. All rights reserved.