The Toxicology Investigators Consortium Case Registry--the 2014 Experience.
The Toxicology Investigators Consortium Case Registry--the 2014 Experience.
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毒理学调查者联盟病例登记——2014 年的经验。
DOI：
10.1007/s13181-015-0507-7
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发表时间：
2015
期刊：
影响因子：
--
通讯作者：
ToxicologyInvestigatorsConsortium
中科院分区：
文献类型：
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作者：
Rhyee,SeanH;Farrugia,Lynn;Campleman,SharanL;Wax,PaulM;Brent,Jeffrey;ToxicologyInvestigatorsConsortium
毒理学调查者联盟 (ToxIC) 病例登记处由美国医学毒理学会于 2010 年建立。登记处包括在参与地点进行的所有医学毒理学咨询。登记处对2014年1月1日至12月31日期间输入的所有病例进行了查询。审查分析的具体数据包括人口统计数据（年龄、性别、种族）、咨询来源、咨询原因、涉及毒理学暴露的物质、体征、症状、临床结果、死亡人数和治疗。 2014 年，47 个活跃会员网站的登记处录入了 9172 起案件。女性占病例的 51.1%。大多数病例 (65.1%) 是 19 岁至 65 岁之间的成年人。白种人是最大的已确定种族群体 (48.9%)。大多数登记案例来自住院部（93.5%），其中大部分咨询来自急诊科或住院部入院服务。有意和无意的药物接触仍然是最常见的咨询原因，占病例的 61.7%。在故意接触药物的案例中，62.4% 与自残企图有关。非药物暴露占登记案例的 14.1%。与过去几年类似，非阿片类镇痛药、镇静催眠药和阿片类药物是最常见的药物。 81.9% 的病例出现临床体征或症状。共有 89 人死亡 (0.97%)。 62.3% 的病例接受了药物治疗（例如解毒剂、抗蛇毒血清、螯合剂、支持治疗）。 2014 年登记病例的患者人口统计和暴露特征与往年相似。大多数咨询发生在急症护理环境（急诊科或住院病人）并涉及接触药品。在暴露中，非阿片类镇痛药、镇静/催眠药和阿片类药物是最常遇到的。大多数病例需要某种形式的治疗，但死亡人数很少。
The Toxicology Investigators Consortium (ToxIC) Case Registry was established in 2010 by the American College of Medical Toxicology. The Registry includes all medical toxicology consultations performed at participating sites. The Registry was queried for all cases entered between January 1 and December 31, 2014. Specific data reviewed for analysis included demographics (age, gender, ethnicity), source of consultation, reasons for consultation, agents involved in toxicological exposures, signs, symptoms, clinical findings, fatalities, and treatment. In 2014, 9172 cases were entered in the Registry across 47 active member sites. Females accounted for 51.1 % of cases. The majority (65.1 %) of cases were adults between the ages of 19 and 65. Caucasians made up the largest identified ethnic group (48.9 %). Most Registry cases originated from the inpatient setting (93.5 %), with a large majority of these consultations coming from the emergency department or inpatient admission services. Intentional and unintentional pharmaceutical exposures continued to be the most frequent reasons for consultation, accounting for 61.7 % of cases. Among cases of intentional pharmaceutical exposure, 62.4 % were associated with a self-harm attempt. Non-pharmaceutical exposures accounted for 14.1 % of Registry cases. Similar to the past years, non-opioid analgesics, sedative-hypnotics, and opioids were the most commonly encountered agents. Clinical signs or symptoms were noted in 81.9 % of cases. There were 89 recorded fatalities (0.97 %). Medical treatment (e.g., antidotes, antivenom, chelators, supportive care) was rendered in 62.3 % of cases. Patient demographics and exposure characteristics in 2014 Registry cases remain similar to prior years. The majority of consultations arose in the acute care setting (emergency department or inpatient) and involved exposures to pharmaceutical products. Among exposures, non-opioid analgesics, sedative/hypnotics, and opioids were the most frequently encountered. A majority of cases required some form of treatment, but fatalities were rare.