Making vitamin C lipophilic enhances its protective effect against free radical induced peroxidation of low density lipoprotein
Making vitamin C lipophilic enhances its protective effect against free radical induced peroxidation of low density lipoprotein
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使维生素 C 具有亲脂性可增强其对自由基诱导的低密度脂蛋白过氧化的保护作用
DOI：
10.1016/s0009-3084(98)00064-4
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发表时间：
1998-09-01
影响因子：
3.4
通讯作者：
Liu, ZL
中科院分区：
文献类型：
--
作者：
Liu, ZQ;Ma, LP;Liu, ZL
人低密度脂蛋白 (LDL) 的过氧化反应由水溶性引发剂 2,2'-偶氮二(2-脒基丙烷盐酸盐) (AAPH) 和铜引发，并分别受到维生素 C (VC) 及其亲脂衍生物抗坏血酸 6-辛酸酯 (VC-8)、6-月桂酸酯 (VC-12) 和 6-棕榈酸酯 (VC-16) 的抑制。通过吸氧量、α-生育酚的衰变和脂质氧化产物的形成来监测过氧化。抗氧化过程的动力学分析表明，VCs可以与LDL中的内源性抗氧化剂（维生素E、泛醇-10、β-胡萝卜素等）协同作用，抑制过氧化，并且亲脂性VCs的协同效应明显高于其疏脂母体分子的协同效应。研究还表明，VC，尤其是亲脂性 VC，在抑制铜诱导的 LDL 过氧化方面比 AAPH 诱导的 LDL 过氧化更有效。 (C) 1998 Elsevier Science Ireland Ltd. 保留所有权利。
The peroxidation of human low density lipoprotein (LDL) was initiated by water-soluble initiator 2,2'-azobis(2-amidinopropane hydrochloride) (AAPH) and copper and inhibited by vitamin C (VC) and its lipophillic derivatives ascorbyl-6-caprylate (VC-8), 6-laurate (VC-12) and 6-palmitate (VC-16), respectively. The peroxidation was monitored by oxygen uptake, by decay of alpha-tocopherol and by formation of lipid oxidation products. Kinetic analysis of the antioxidation process demonstrates that the VCs can work synergistically with endogenous antioxidants (vitamin E, ubiquinol-10, beta-carotene etc.) in LDL to suppress the peroxidation and that the synergistic effect of the lipophilic VCs is appreciably higher than that of their lipophobic parent molecule. It is also shown that VC and especially the lipophilic VCs, are much more effective in inhibition of copper-induced than AAPH-induced LDL peroxidation. (C) 1998 Elsevier Science Ireland Ltd. Ail rights reserved.