Firing patterns and correlations of spontaneous discharge of pallidal neurons in the normal and the tremulous 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine vervet model of parkinsonism
Firing patterns and correlations of spontaneous discharge of pallidal neurons in the normal and the tremulous 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine vervet model of parkinsonism
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DOI：
10.1523/jneurosci.20-22-08559.2000
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发表时间：
2000-11-15
影响因子：
5.3
通讯作者：
Bergman, H
中科院分区：
文献类型：
--
作者：
Raz, A;Vaadia, E;Bergman, H
为了研究基底节区在帕金森震颤中的作用，我们记录了两只黑尾猴在接受1-甲基-4-苯基-1,2,3,6-四氢吡啶（MPTP）治疗前后的手部震颤和白球外节和内节几个神经元的同时活动，以及帕金森震颤的发展，震颤频率为5和11 Hz。在健康猴子中，只有11%（20/174）的GPe细胞和3%（1/29）的GPi细胞表现出明显的3- 19hz振荡。MPTP处理后，39%（107/271）的GPe细胞和43%（26/61）的GPi细胞出现明显的振荡。MPTP处理后的单细胞振荡频率在7和13 Hz左右呈双峰分布。在震颤期间记录的振荡细胞中，有10%的细胞有明显的震颤和神经元振荡同时出现的趋势。交叉相关分析显示，正常状态下，苍白叶神经元之间的相关活动水平非常低；95.6%（477/499）对不相关，仅有1%（5/499）对存在振荡交叉相关。在MPTP治疗后，相关性显著增加，40%（432/1080）的交叉相关图有显著的振荡，以13-14 Hz为中心。GPe对互相关图的相移在0度左右聚集，而GPi对则没有。结果表明，MPTP治疗改变了GPe和GPi的活动模式和同步。这些变化与帕金森氏症的症状有关，特别是与帕金森氏震颤有关。
To investigate the role of the basal ganglia in parkinsonian tremor, we recorded hand tremor and simultaneous activity of several neurons in the external and internal segments of the globus pallidus (GPe and GPi) in two vervet monkeys, before and after systemic treatment with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and development of parkinsonism with tremor of 5 and 11 Hz.In healthy monkeys, only 11% (20/174) of the GPe cells and 3% (1/29) of the GPi cells displayed significant 3-19 Hz oscillations. After MPTP treatment, 39% (107/271) of the GPe cells and 43% (26/61) of the GPi cells developed significant oscillations. Oscillation frequencies of single cells after MPTP treatment were bimodally distributed around 7 and 13 Hz. For 10% of the oscillatory cells that were recorded during tremor periods, there was a significant tendency for the tremor and neuronal oscillations to appear simultaneously.Cross-correlation analysis revealed a very low level of correlated activity between pallidal neurons in the normal state; 95.6% (477/499) of the pairs were not correlated, and oscillatory cross-correlograms were found in only 1% (5/499) of the pairs. After MPTP treatment, the correlations increased dramatically, and 40% (432/1080) of the cross-correlograms had significant oscillations, centered around 13-14 Hz. Phase shifts of the cross-correlograms of GPe pairs, but not of GPi, were clustered around 0 degrees.The results illustrate that MPTP treatment changes the pattern of activity and synchronization in the GPe and GPi. These changes are related to the symptoms of Parkinson's disease and especially to the parkinsonian tremor.