Biophysical mechanisms of cardiac looping
Biophysical mechanisms of cardiac looping
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DOI：
10.1387/ijdb.052045lt
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发表时间：
2006-01-01
影响因子：
0.7
通讯作者：
Taber, LA
中科院分区：
文献类型：
--
作者：
Taber, LA
在早期胚胎发育过程中，心脏是一个相对直立的管子，向右弯曲和扭转(环状)，形成成熟心脏的基本平面。尽管几十年来一直在进行深入的研究，但驱动和调节心脏环路的生物物理机制仍然知之甚少。本文从历史的角度讨论了对环路力学的研究以及针对这一复杂过程提出的各种理论。然后，基于最近获得的数据，提出了一种新的生物力学假说，用于第一阶段的环行(c-环行)。了解形态发生机制将促进致力于预防和治疗由环状畸形引起的先天性心脏畸形的研究。
During early embryogenesis, the heart is a single, relatively straight tube which bends and twists (loops) rightward to create the basic plan of the mature heart. Despite intensive study for many decades, the biophysical mechanisms which drive and regulate cardiac looping have remained poorly understood. This review discusses, from a historical perspective, studies of looping mechanics and various theories which have been proposed for this complex process. Then, based on recently acquired data, a new biomechanical hypothesis is proposed for the first phase of looping (c-looping). Understanding morphogenetic mechanisms would facilitate research devoted to preventing and treating congenital heart malformations caused by looping abnormalities.