Heritability and reliability of P300, P50 and duration mismatch negativity
Heritability and reliability of P300, P50 and duration mismatch negativity
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DOI：
10.1007/s10519-006-9091-6
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发表时间：
2006-11-01
影响因子：
2.6
通讯作者：
Sham, Pak
中科院分区：
文献类型：
--
作者：
Hall, Mei Hua;Schulze, Katja;Sham, Pak
背景事件相关电位（ERP）被认为是精神分裂症的可能内表型。方法采用19导脑电图（EEG）记录40对健康同卵双生子（其中19对为双卵双生子）和30对双卵双生子的ERP成分（P300、P50和MMN）。结果P300波幅及其潜伏期、MMN波幅和P50抑制率成分的可靠性较高。P300波幅和P300潜伏期的ICC值分别为0.86和0.88。MMN峰值和平均振幅的信度分别为0.67和0.66。P50 T/C比值信度为0.66。模型拟合分析表明，这些ERP措施的方差有很大的遗传性或家族成分。MMN峰值振幅和平均振幅的遗传率估计分别为63%和68%。对于P50 T/C比值，估计遗传力为68%。P300振幅的遗传率估计为69%，而一个显着的家族效应被发现P300潜伏期有足够的权力来区分共享的环境和遗传factors.Conclusions的高可靠性和遗传性的P300振幅，MMN振幅，P50抑制比组件支持他们使用的候选endophenotypes精神病学研究。
Background Event-related potentials (ERPs) have been suggested as possible endophenotypes of schizophrenia. We investigated the test-retest reliabilities and heritabilities of three ERP components in healthy monozygotic and dizygotic twin pairs.Methods ERP components (P300, P50 and MMN) were recorded using a 19-channel electroencephalogram (EEG) in 40 healthy monozygotic twin pairs, 19 of them on two separate occasions, and 30 dizygotic twin pairs. Zygosity was determined using DNA genotyping.Results High reliabilities were found for the P300 amplitude and its latency, MMN amplitude, and P50 suppression ratio components. ICC = 0.86 and 0.88 for the P300 amplitude and P300 latency respectively. Reliability of MMN peak amplitude and mean amplitude were 0.67 and 0.66 respectively. P50 T/C ratio reliability was 0.66. Model fitting analyses indicated a substantial heritability or familial component of variance for these ERP measures. Heritability estimates were 63 and 68% for MMN peak amplitude and mean amplitude respectively. For P50 T/C ratio, 68% heritability was estimated. P300 amplitude heritability was estimated at 69%, and while a significant familiality effect was found for P300 latency there was insufficient power to distinguish between shared environment and genetic factors.Conclusions The high reliability and heritability of the P300 amplitude, MMN amplitude, and P50 suppression ratio components supports their use as candidate endophenotypes for psychiatric research.