Protective properties of vaccinia virus-based vaccines: skin scarification promotes a nonspecific immune response that protects against orthopoxvirus disease.
Protective properties of vaccinia virus-based vaccines: skin scarification promotes a nonspecific immune response that protects against orthopoxvirus disease.
复制标题
基于牛痘病毒的疫苗的保护特性：皮肤划痕可促进非特异性免疫反应，从而预防正痘病毒疾病。
DOI：
10.1128/jvi.00185-14
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发表时间：
2014
影响因子：
5.4
通讯作者：
Moyer,RichardW
中科院分区：
文献类型：
--
作者：
Rice,AmandaD;Adams,MathewM;Lindsey,ScottF;Swetnam,DanieleM;Manning,BrandiR;Smith,AndrewJ;Burrage,AndrewM;Wallace,Greg;MacNeill,AmyL;Moyer,RichardW
The process of vaccination introduced by Jenner generated immunity against smallpox and ultimately led to the eradication of the disease. Procedurally, in modern times, the virus is introduced into patients via a process called scarification, performed with a bifurcated needle containing a small amount of virus. What was unappreciated was the role that scarification itself plays in generating protective immunity. In rabbits, protection from lethal disease is induced by intradermal injection of vaccinia virus, whereas a protective response occurs within the first 2 min after scarification with or without virus, suggesting that the scarification process itself is a major contributor to immunoprotection.IMPORTANCEThese results show the importance of local nonspecific immunity in controlling poxvirus infections and indicate that the process of scarification should be critically considered during the development of vaccination protocols for other infectious agents.
