Baroreflex control of arterial and venous compliances and vascular capacity in hypertensive dogs.
Baroreflex control of arterial and venous compliances and vascular capacity in hypertensive dogs.
复制标题
压力反射控制高血压犬的动脉和静脉顺应性以及血管容量。
DOI：
10.1152/ajpheart.1993.265.1.h96
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发表时间：
1993
期刊：
影响因子：
--
通讯作者：
Brunner,MJ
中科院分区：
文献类型：
--
作者：
Bishop,GG;Shigemi,K;Freeman,JP;Brunner,MJ
在戊巴比妥钠麻醉下，在慢性高血压（一肾一夹）和假手术血压正常的狗中研究了颈动脉窦压力感受器反射引起血管容量反射变化的能力。测量血管顺应性和反射引起的外部储液器容积的变化，以响应单独颈动脉窦压（CSP）的变化。平均动脉压-CSP反射特征曲线随着高血压向更高的动脉压移动，而最大反射增益没有变化。当CSP从50增加到200 mmHg时，两组的动脉顺应性均显著增加（P < 0.01）。总的，动脉，静脉血管顺应性在正常血压和高血压组之间没有差异。CSP的变化不会导致全身血管顺应性或计算的静脉顺应性发生显著变化。CSP从250 mmHg降低至50 mmHg，导致正常血压组和高血压组的外部储血器容积分别增加8.02 +/- 1.03和7.44 +/- 1.33 ml/kg，静脉容积变化分别为11.99 +/- 1.39和12.58 +/- 1.52 ml/kg（NS）。我们的结论是，尽管动脉阻力增加，Goldblatt高血压犬保留的能力，使短期的反射调整动脉压和静脉血容量。
The ability of the carotid sinus baroreflex to elicit reflex changes in vascular capacity was studied in chronically hypertensive (one-kidney, one-clip) and sham-operated normotensive dogs under pentobarbital sodium anesthesia. Vascular compliances and reflex-induced changes in external reservoir volume were measured in response to changes in isolated carotid sinus pressure (CSP). The mean arterial pressure-CSP reflex characteristic curve was shifted to a higher arterial pressure with hypertension with no change in maximum reflex gains. Arterial compliance in both groups increased significantly (P < 0.01) when CSP was increased from 50 to 200 mmHg. Total, arterial, and venous vascular compliances were not different in normotensive and hypertensive groups. Changes in CSP caused no significant changes in either total systemic vascular or calculated venous compliances. A decrease in CSP from 250 to 50 mmHg resulted in an increase in external reservoir volume of 8.02 +/- 1.03 and 7.44 +/- 1.33 ml/kg in normotensive and hypertensive groups, respectively, with changes in venous volume of 11.99 +/- 1.39 and 12.58 +/- 1.52 ml/kg (NS). We conclude that despite the increase in arterial resistance, Goldblatt hypertensive dogs retain the ability to make short-term reflex adjustments in both arterial pressure and venous blood volume.