Relative potency of PAHs and heterocycles as aryl hydrocarbon receptor agonists in fish
Relative potency of PAHs and heterocycles as aryl hydrocarbon receptor agonists in fish
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DOI：
10.1016/j.marenvres.2004.03.001
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发表时间：
2004-08-01
影响因子：
3.3
通讯作者：
Rice, SD
中科院分区：
文献类型：
--
作者：
Barron, MG;Heintz, R;Rice, SD
本文利用18篇已发表的论文中的CYP1A诱导或AhR结合74种多环芳烃（PAHs）和杂环化合物的数据，确定了多环芳烃化合物在鱼类中作为芳烃受体（AhR）激动剂的相对效力。每个多环芳烃被赋予了一个相对于作为AhR激动剂的2,3,7,8-四氯二苯并-对二恶英效力的鱼类效力因子。二环和三环未取代多环芳烃在鱼类、鸟类和哺乳动物系统中普遍无活性。苯并[k]荧光蒽和茚二[1,2,3-cd]芘始终是最有效的多环芳烃，其鱼效因子为0.001-0.002。与效能较高的多环芳烃相关的常见结构特征包括含有氟蒽的4-6环或具有暴露湾区的菲结构。这些结果表明，多环芳烃可能与许多二恶英样多氯联苯具有相似的效力，在评估鱼类中多环芳烃的风险时应考虑AhR介导的毒性。(C) 2004 Elsevier Ltd.版权所有。
The relative potency of polycyclic aromatic compounds as aryl hydrocarbon receptor (AhR) agonists in fish was determined using data on CYP1A induction or AhR binding for 74 polycyclic aromatic hydrocarbons (PAHs) and heterocycles in teleost, avian, or mammalian systems from 18 published papers. Each PAH was assigned a fish potency factor relative to the potency of 2,3,7,8-tetrachlorodibenzo-p-dioxin as an AhR agonist. Two and three ring unsubstituted PAHs were generally inactive in fish, avian, and mammalian systems. Benzo[k]fluoranthene and indeno[1,2,3-cd]pyrene were consistently the most potent PAHs, with fish potency factors of 0.001-0.002. Common structural features associated with higher potency PAHs included 4-6 rings containing fluoranthene or phenanthrene structures with an exposed bay region. These results show that PAHs can have similar potency as many dioxin-like PCBs, and AhR mediated toxicity should be considered in assessing the risks of PAHs in fish. (C) 2004 Elsevier Ltd. All rights reserved.