DISAPPEARANCE AND REAPPEARANCE OF HIGH ENDOTHELIAL VENULES AND IMMIGRATING LYMPHOCYTES IN LYMPH-NODES DEPRIVED OF AFFERENT LYMPHATIC VESSELS - A POSSIBLE REGULATORY ROLE OF MACROPHAGES IN LYMPHOCYTE MIGRATION
DISAPPEARANCE AND REAPPEARANCE OF HIGH ENDOTHELIAL VENULES AND IMMIGRATING LYMPHOCYTES IN LYMPH-NODES DEPRIVED OF AFFERENT LYMPHATIC VESSELS - A POSSIBLE REGULATORY ROLE OF MACROPHAGES IN LYMPHOCYTE MIGRATION
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DOI：
10.1002/eji.1830130811
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发表时间：
1983-01-01
影响因子：
5.4
通讯作者：
EESTERMANS, IL
中科院分区：
文献类型：
--
作者：
HENDRIKS, HR;EESTERMANS, IL
阻断大鼠腘淋巴结（LN）的输入淋巴管，在3 wk内可引起高内皮微静脉（HEV）和移入淋巴细胞的消失。HEV表现出几种特征性的形态学变化：内皮细胞变平，嗜派若宁性减少，染色质浓缩，蛋白质合成和分泌细胞器变得稀少。同时，LN中的巨噬细胞数量严重减少。 术后6 wk，注入绵羊红细胞，可使HEV和移入的淋巴细胞重新出现，并出现大量浆细胞和生殖中心。[大肠杆菌]脂多糖注射到操作LN导致出现许多浆细胞和一些发育不良的生发中心; HEV和移民淋巴细胞仍然几乎不存在。结果表明，淋巴细胞的迁移与内皮细胞的活性之间的关系在戊型肝炎病毒。后者的激活可能通过由抗原刺激的巨噬细胞和T细胞释放的介质发生。HEV的形态特征与再循环淋巴细胞的存在无关。
Interruption of the afferent lymphatic vessels of the popliteal lymph node [LN] in rats resulted in the disappearance of high endothelial venules (HEV) and immigrating lymphocytes within 3 wk. HEV showed several characteristic morphological changes: the endothelial cells became flattened and less pyroninophilic, the chromatin became condensed, and protein synthetizing and secretory cell organelles became scarce. At the same time, the number of macrophages in the LN was severely reduced. Injection of sheep red blood cells into such LN, 6 wk after operation, resulted in reappearance of HEV and immigrating lymphocytes and development of many plasma cells and some germinal centers. Injection of [Escherichia coli] lipopolysaccharide into the operated LN resulted in the appearance of many plasma cells and a few poorly developed germinal centers; HEV and immigrating lymphocytes remained almost absent. The results show a relationship between the immigration of lymphocytes and the activity of the endothelial cells in the HEV. The activation of the latter may occur by mediators released by antigen-stimulated macrophages and T cells. The morphological features of the HEV are independent of the presence of recirculating lymphocytes.