Protein tyrosine phosphatases: structure, function, and implication in human disease.
Protein tyrosine phosphatases: structure, function, and implication in human disease.
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DOI：
10.1007/978-1-62703-562-0_13
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发表时间：
2013
期刊：
影响因子：
--
通讯作者：
Grotegut S
中科院分区：
文献类型：
--
作者：
Tautz L;Critton DA;Grotegut S
蛋白质酪氨酸磷酸化是真核细胞生理学中的关键调节机制。蛋白酪氨酸激酶和蛋白酪氨酸磷酸酶的异常表达或功能可导致严重的人类疾病，包括癌症、糖尿病以及心血管、感染性、自身免疫和神经精神疾病。在这里，我们给出了一个概述的蛋白酪氨酸磷酸酶超家族，其超过100个成员在人类。我们回顾了它们的结构，功能和在人类疾病中的意义，并讨论了它们作为新型药物靶点的潜力，以及目前的挑战和基于这些酶开发治疗方法的可能解决方案。
Protein tyrosine phosphorylation is a key regulatory mechanism in eukaryotic cell physiology. Aberrant expression or function of protein tyrosine kinases and protein tyrosine phosphatases can lead to serious human diseases, including cancer, diabetes, as well as cardiovascular, infectious, autoimmune, and neuropsychiatric disorders. Here, we give an overview of the protein tyrosine phosphatase superfamily with its over 100 members in humans. We review their structure, function, and implications in human diseases, and discuss their potential as novel drug targets, as well as current challenges and possible solutions to developing therapeutics based on these enzymes.