Conosilane A, an Unprecedented Sesquiterpene from the Cultures of Basidiomycete Conocybe siliginea
Conosilane A, an Unprecedented Sesquiterpene from the Cultures of Basidiomycete Conocybe siliginea
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康诺硅烷 A，一种来自担子菌 Conocybe siliginea 培养物的前所未有的倍半萜
DOI：
10.1021/ol302468a
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发表时间：
2012-10-19
期刊：
影响因子：
5.2
通讯作者：
Liu, Ji-Kai
中科院分区：
文献类型：
--
作者：
Yang, Xiao-Yan;Feng, Tao;Liu, Ji-Kai
康诺硅烷A(1)是从担子菌硅藻中分离得到的一种新的倍半萜类化合物，具有前所未有的碳骨架。用广谱方法确定了其结构，用单晶X-射线衍射分析确定了其绝对构型。对11β-羟基类固醇脱氢酶有明显的抑制作用。
Conosilane A (1), a novel sesquiterpene with an unprecedented carbon skeleton, was isolated from the cultures of the basidiomycete Conocybe siliginea. Its structure was elucidated by extensive spectroscopic methods, and the absolute configuration was determined by single crystal X-ray diffraction analysis. Conosilane A was found to inhibit 11 beta-hydroxysteroid dehydrogenase significantly.