The effect of formaldehyde exposure upon the mononuclear phagocyte system of mice.
The effect of formaldehyde exposure upon the mononuclear phagocyte system of mice.
复制标题
甲醛暴露对小鼠单核吞噬细胞系统的影响。
DOI：
10.1016/0041-008x(87)90002-0
复制
发表时间：
1987
影响因子：
3.8
通讯作者：
Dean,JH
中科院分区：
文献类型：
--
作者：
Adams,DO;Hamilton,TA;Lauer,LD;Dean,JH
据报道，甲醛蒸气对健康有潜在的危害，导致实验动物鼻甲癌症的发生率增加。为了确定吸入甲醛引起的单核巨噬细胞系统(MPS)改变的潜在作用，我们研究了吸入甲醛对巨噬细胞的全身影响。具体地说，我们利用已建立的定量客观标记物系统，研究了甲醛暴露对MPS发育的影响，该系统表征了小鼠巨噬细胞群体并将其划分为几个发育阶段。小鼠每天暴露在15ppm的甲醛中6小时，连续3周，并没有改变常驻的腹膜巨噬细胞的数量或损害其功能，尽管这种暴露增加了(大约两倍)从巨噬细胞释放过氧化氢的能力。此外，甲醛暴露并没有改变由确定的刺激剂MVE-2产生的巨噬细胞的杀瘤激活或分化。因此，数据表明，暴露在甲醛中的小鼠可以诱导MPS产生过氧化氢的功能发生选择性的系统性变化，这种变化已经在其他研究中显示出，以增加突变的频率。
The vapors of formaldehyde have been reported to represent a potential health hazard, resulting in an increased incidence of carcinomas of the nasal turbinates in experimental animals. To determine the potential role of alterations in the mononuclear phagocyte system (MPS) induced by inhalation of formaldehyde, we studied the systemic effects of exposure upon macrophages. Specifically, we examined the effects of formaldehyde exposure upon development of the MPS by use of an established system of quantitative objective markers, which characterizes and classifies populations of murine macrophages into several developmental stages. Exposure of mice to 15 ppm of formaldehyde for 6 hr daily for 3 weeks did not alter the number or impair the function of resident peritoneal macrophages, although this exposure increased (approximately twofold) competence for release of H2O2from the macrophages. Furthermore, formaldehyde exposure did not alter the tumoricidal activation or differentiation of macrophages produced by the defined stimulant MVE-2. The data thus indicate that exposure of mice to formaldehyde can induce selective systemic alterations in the function of the MPS for H2O2production, a change which has been shown in other studies to increase the frequency of mutagenesis.