Association of polymorphisms in the RAGE gene with serum CRP levels and coronary artery disease in the Chinese Han population
Association of polymorphisms in the RAGE gene with serum CRP levels and coronary artery disease in the Chinese Han population
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DOI：
10.1038/jhg.2010.85
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发表时间：
2010-10-01
影响因子：
3.5
通讯作者：
Xu, Dingli
中科院分区：
文献类型：
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作者：
Gao, Jinxiong;Shao, Yahui;Xu, Dingli
糖基化终产物/糖基化终产物受体(AGE/RAGE)系统在冠心病(CAD)发病机制中的作用尚不完全清楚。为了阐明RAGE基因多态性是否与冠心病相关，我们在中国汉族患者中进行了一项病例对照研究。比较200例高血压病患者、155例冠心病合并高血压患者、175例冠心病患者和170例对照组RAGE基因-429T/C、1704G/T和G82S等位基因频率及基因型分布组合。采用聚合酶链式反应-限制性片段长度多态性方法检测基因变异。S等位基因G82S多态性在冠心病中的分布频率较高(优势比2.303，95%可信区间1.553~3.416；P
The role of an advanced glycation end product/receptor for advanced glycation end product (AGE/RAGE) system in the pathogenesis of coronary artery disease (CAD) is not fully understood. To clarify whether polymorphisms of the RAGE gene were related to CAD, we performed a case-control study in Chinese Han patients. The allele frequencies and genotype distribution combinations of the -429T/C, 1704G/T and G82S polymorphisms of the RAGE gene were compared in 200 cases of hypertension (HT), 155 cases of CAD combined with HT (CAD&HT), 175 cases of CAD and 170 control subjects. Polymerase chain reaction-restriction fragment length polymorphism was used for detection of genotypic variants. The S allele frequency of the G82S polymorphism was higher in the CAD (odds ratio (OR), 2.303, 95% confidence interval (CI) 1.553-3.416; P