NASOPHARYNGEAL COLONIZATION WITH NONTYPABLE HAEMOPHILUS-INFLUENZAE AND RECURRENT OTITIS-MEDIA
NASOPHARYNGEAL COLONIZATION WITH NONTYPABLE HAEMOPHILUS-INFLUENZAE AND RECURRENT OTITIS-MEDIA
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DOI：
10.1093/infdis/170.4.862
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发表时间：
1994-10-01
影响因子：
6.4
通讯作者：
KRYSTOFIK, D
中科院分区：
文献类型：
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作者：
HARABUCHI, Y;FADEN, H;KRYSTOFIK, D
鼻咽部定植与不可分型H。对157名从出生到12个月大的儿童进行了前瞻性随访，评估了流感和复发性中耳炎的情况。49个（31%）成为殖民地。鼻咽分泌型伊加（sIgA）与P6外膜蛋白的反应，检测在所有殖民儿童。减少或消除微生物与更好的粘膜免疫应答（560 +/- 864单位/ng/ml sIgA）相关，而不是鼻咽中的持久性（121 +/- 81; P = .04）。40名定植儿童（82%）和61名非定植儿童（56%）发生中耳炎（P = 0.004）;定植儿童被归类为易发性中耳炎的可能性高4倍（P = 0.003）。中耳炎发作频率与定植频率直接相关（r = 0.42，P <0.01）。这些结果表明，鼻咽定植模式和中耳炎之间有很强的关系。粘膜免疫应答可能在从呼吸道消除潜在病原体中起重要作用。
The relationship between nasopharyngeal colonization with nontypeable H. influenzae and recurrent otitis media was assessed in 157 children followed prospectively from birth through 12 months of age. Forty-nine (31%) became colonized. Nasopharyngeal secretory IgA (sIgA) reactive with the P6 outer membrane protein was detected in all colonized children. Reduction or elimination of the organism was associated with a better mucosal immune response (560 +/- 864 units/ng/ml of sIgA) than was persistence in the nasopharynx (121 +/- 81; P = .04). Forty colonized children (82%) and 61 noncolonized children (56%) developed otitis media (P = .004); colonized children were four times more likely to be classified as otitis prone (P = .003). The frequency of otitis media episodes was directly related to the frequency of colonization (r = .42, P < .01). These results demonstrate a strong relationship between nasopharyngeal colonization patterns and otitis media. The mucosal immune response may be important in elimination of potential pathogens from the respiratory tract.