Gelatinases A and B (MMP-2 and MMP-9) in endometrial cancer -: MMP-9 correlates to the grade and the stage
Gelatinases A and B (MMP-2 and MMP-9) in endometrial cancer -: MMP-9 correlates to the grade and the stage
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DOI：
10.1016/j.ygyno.2004.06.028
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发表时间：
2004-09-01
影响因子：
4.7
通讯作者：
Stendahl, U
中科院分区：
文献类型：
--
作者：
Aglund, K;Rauvala, M;Stendahl, U
客观的。基质金属蛋白酶 (MMP) 与多种恶性肿瘤的攻击行为有关。明胶酶（MMP-2 和 MMP-9）尤其是许多腺癌和上皮癌的预后因素。然而，尚无关于明胶酶在子宫内膜癌中的作用的结论性数据。方法。 1988 年至 1993 年间在于默奥大学医院接受治疗的 88 名子宫内膜癌患者被纳入其中。使用特异性单克隆抗体对石蜡包埋组织中的 MMP-2 和 MMP-9 蛋白进行免疫组织化学分析。将染色结果与临床数据进行比较。结果。 52% 的病例 MMP-9 呈阳性，72% 的病例 MMP-2 呈阳性。 MMP-2 或 MMP-9 蛋白的过度表达与较差的生存率相关。 MMP-2 表达的预测价值在 1 期癌症中最为明显。发现 MMP-2 和 MMP-9 的阳性率之间存在关联。只有 3% 的病例对两种明胶酶均呈高度阳性，18% 的病例对两种 MMP 均呈阴性。两种明胶酶均与组织学分级相关。 MMP-9 还与疾病的临床分期相关，而 MMP-2 则不然。与浸润深度、绝经状态或患者年龄没有明显关联。结论。 MMP-2和MMP-9可以作为子宫内膜癌临床行为的标志物。它们可能进一步与癌症复发的倾向有关。因此，这些明胶酶可能有助于做出是否需要辅助治疗的决策。 (C) 2004 Elsevier Inc. 保留所有权利。
Objective. Matrix metalloproteinases (MMPs) have been linked to aggressive behavior in several malignancies. Gelatinases (MMP-2 and MMP-9) in particular are prognostic factors in many adeno- and epithelial cancers. However, no conclusive data exist concerning the role of gelatinases in endometrial cancer.Methods. Eighty-eight patients with endometrial cancer, treated between 1988 and 1993 in Umea University Hospital, were included. MMP-2 and MMP-9 proteins were analyzed immunohistochemically from paraffin-embedded tissues by using specific monoclonal antibodies. The staining results were compared to the clinical data.Results. Fifty-two percent of the cases were positive for MMP-9 and 72% for MMP-2. The overexpression of the proteins of either MMP-2 or MMP-9 was associated with poor survival. The predictive value of MMP-2 expression was most distinct in stage 1 cancers. An association was found between the positivity of MMP-2 and MMP-9. Only 3% of the cases were highly positive for both gelatinases and 18% of the cases were negative for both MMPs. Both gelatinases correlated to the histological grade. MMP-9 also correlated to the clinical stage of the disease, whereas MMP-2 did not. There was no apparent association with either depth of invasion, menopausal status, or the age of the patient.Conclusion. MMP-2 and MMP-9 could serve as markers for the clinical behavior of endometrial cancer. They may further be linked to a tendency to cancer relapse. Thus, these gelatinases may turn out to be potentially useful in decision making about the need for an adjuvant treatment. (C) 2004 Elsevier Inc. All rights reserved.