Insulin resistance and prostate cancer risk
Insulin resistance and prostate cancer risk
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DOI：
10.1093/jnci/95.1.67
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发表时间：
2003-01-01
期刊：
影响因子：
--
通讯作者：
Stanczyk, FZ
中科院分区：
文献类型：
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作者：
Hsing, AW;Gao, YT;Stanczyk, FZ
由于高腰臀比（WHR）和高血清胰岛素水平与前列腺癌风险增加有关，我们评估了胰岛素抵抗与中国男性前列腺癌风险之间的关系。我们测定了128例糖尿病患者和306例正常对照者的空腹血糖和胰岛素水平，并采用稳态模型评估法得出胰岛素敏感性和抵抗指数。相对于最低三分位数的男性，胰岛素敏感性最高三分位数的男性患前列腺癌的风险降低（比值比[OR] = 0.35，95%置信区间[CI] = 0.21至0.60），但胰岛素抵抗最高三分位数的男性患前列腺癌的风险增加（OR = 2.78，95% CI = 1.63至4.72）。综合考虑胰岛素抵抗和腰臀比，胰岛素抵抗的影响在腰臀比的所有三分位数中都很明显，胰岛素抵抗和腰臀比最高的三分位数的男性具有最高的风险（OR = 8.21，95%CI = 2.84至23.70）。前列腺癌风险与胰岛素敏感性或抵抗之间的关联与总热量摄入和血清胰岛素样生长因子、性激素和性激素结合球蛋白水平无关。由于本研究的回顾性设计，胰岛素抵抗在前列腺癌中的作用需要在前瞻性研究中证实。
Because high waist-to-hip ratio (WHR) and high serum insulin levels have been reported to be associated with an increased risk of prostate cancer, we assessed the relationship between insulin resistance and prostate cancer risk in Chinese men. We measured fasting serum glucose and insulin levels in 128 case and 306 control subjects and used the homeostasis model assessment to derive indices of insulin sensitivity and resistance. Relative to men in the lowest tertiles, men in the highest tertile of insulin sensitivity had a reduced risk of prostate cancer (odds ratio [OR] = 0.35, 95% confidence interval [CI] = 0.21 to 0.60), but men in the highest tertile of insulin resistance had an increased risk of prostate cancer (OR = 2.78, 95% CI = 1.63 to 4.72). Considering insulin resistance and WHR together, the effect of insulin resistance was apparent in all tertiles of WHR, with men in the highest tertile of insulin resistance and WHR having the highest risk (OR = 8.21, 95% CI = 2.84 to 23.70). The associations between prostate cancer risk and insulin sensitivity or resistance were independent of total caloric intake and serum levels of insulin-like growth factors, sex hormones, and sex hormone-binding globulin. Because of the retrospective design of this study, the role of insulin resistance in prostate cancer needs to be confirmed in prospective studies.