The stimulation of dendritic cells by amyloid beta 1-42 reduces BDNF production in Alzheimer's disease patients
The stimulation of dendritic cells by amyloid beta 1-42 reduces BDNF production in Alzheimer's disease patients
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DOI：
10.1016/j.bbi.2013.04.001
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发表时间：
2013-08-01
影响因子：
15.1
通讯作者：
Bossu, Paola
中科院分区：
文献类型：
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作者：
Ciaramella, Antonio;Salani, Francesca;Bossu, Paola
树突状细胞（Dendritic cells，DCs）是免疫反应和炎症反应的主要参与者，可能在阿尔茨海默病（Alzheimer 'sdisease，AD）中发挥重要作用。最近的研究表明，在淀粉样β（1-42）肽（A β（1 - 42））存在下体外产生的单核细胞衍生的DC（MDDC）显示出功能改变和炎性分子产生增加。因此，来自AD患者的MDDC显示出比从对照受试者获得的DC更显著的促炎性特征。在这项研究中，我们旨在进一步研究DC在AD中的作用。因此，我们分析了与对照受试者相比，A β（1-42）治疗对来自AD患者的已经分化的DC的体外作用。我们发现，A β（1-42）显着降低脑源性神经营养因子（BDNF）的表达在DC来自AD患者，但不是从对照组。因此，可能由于它们的A β诱导的对神经元的神经营养支持的减少，来自AD患者的DC可能通过在A β依赖性神经元毒性中发挥作用而促成脑损伤。(C)2013 Elsevier Inc. All rights reserved.
Dendritic cells (DCs), the main actors of immune responses and inflammation, may play a role in Alzheimer's disease (AD). Recent studies demonstrate that monocyte-derived DCs (MDDCs), generated in vitro in the presence of amyloid beta(1-42) peptide (A beta(1-42)), show a functional alteration and an increased production of inflammatory molecules. Accordingly, MDDCs from AD patients show a more pronounced pro-inflammatory profile than DCs obtained from control subjects. In this study, we aimed at further investigating DC role in AD. Thus, we analyzed the in vitro effect of A beta(1-42) treatment on already differentiated DCs from AD patients, as compared to control subjects. We found that A beta(1-42) significantly decreases the expression of brain-derived neurotrophic factor (BDNF) in DCs derived from AD patients but not from control subjects. Thus, possibly due to their A beta-induced reduction of neurotrophic support to neurons, DCs from AD patients might contribute to brain damage by playing a part in A beta-dependent neuronal toxicity. (C) 2013 Elsevier Inc. All rights reserved.