Orai1: A New Therapeutic Target for the Acute Kidney Injury-to-Chronic Kidney Disease Transition.
Orai1: A New Therapeutic Target for the Acute Kidney Injury-to-Chronic Kidney Disease Transition.
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Orai1：急性肾损伤向慢性肾病转变的新治疗靶点。
作者：
Basile DP;Collett JA
This review focuses on the potential mediation in the AKI-to-CKD transition by lymphocytes. We highlight evidence that lymphocytes, particularly Th17 cells, modulate the severity of both acute injury and chronic kidney disease. Th17 cells are strongly influenced by the activity of the store-operated Ca2+-channel Orai1, which is upregulated on lymphocytes in animal models of AKI. Inhibition of this channel attenuates both acute and chronic kidney injury in rodent models. In addition, Oria1+ cells are increased in peripheral blood of patients with AKI. Similarly, peripheral blood cells manifest an early and sustained increase in Orai1 expression in a rat model of ischemia/reperfusion, suggesting that blood cell Orai1 may represent a marker informing potential Th17 activity in the setting of AKI or the AKI-to-CKD transition.
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影响因子：
19.6
作者：
Mehrotra P;Patel JB;Ivancic CM;Collett JA;Basile DP
通讯作者：
Basile DP
影响因子：
41.5
作者：
Ferenbach, David A.;Bonventre, Joseph V.
通讯作者：
Bonventre, Joseph V.
DOI：
10.1152/ajprenal.00462.2016
发表时间：
2017-03-01
影响因子：
4.2
作者：
Mehrotra, Purvi;Collett, Jason A.;Basile, David P.
通讯作者：
Basile, David P.
阻断 Orai1 商店运营的钙进入可预防肾纤维化
影响因子：
13.6
作者：
Mai, Xiaoyi;Shang, Jinyan;Zhou, Jiaguo
通讯作者：
Zhou, Jiaguo
DOI：
10.1152/ajprenal.00229.2005
发表时间：
2006-11-01
影响因子：
4.2
作者：
Burne-Taney, Melissa J.;Liu, Manchang;Rabb, Hamid
通讯作者：
Rabb, Hamid