Early life stress and chronic variable stress in adulthood interact to influence methamphetamine self-administration in male rats.
Early life stress and chronic variable stress in adulthood interact to influence methamphetamine self-administration in male rats.
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DOI：
10.1097/fbp.0000000000000166
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发表时间：
2016-04
影响因子：
1.6
通讯作者：
Olive MF
中科院分区：
文献类型：
--
作者：
Lewis CR;Staudinger K;Tomek SE;Hernandez R;Manning T;Olive MF
早期生活压力与成年压力相互作用，以不同方式调节神经系统和各种精神疾病的脆弱性。然而，早期生活压力和成年压力对成瘾行为的影响还没有得到充分的研究。我们研究了早期生活压力的影响，长期的母亲分离的形式，随后在成年早期的10天的慢性可变压力或无压力的甲基苯丙胺自我管理，灭绝和线索诱导的恢复。我们观察到，在成年期的慢性可变压力减少了甲基苯丙胺自我管理的历史，早期生活压力的大鼠。这些研究结果增加了一个新兴的文学机构之间的相互作用和早期生活和成年早期的压力对成年人的行为表型。
Early life stress interacts with adult stress to differentially modulate neural systems and vulnerability to various psychiatric illnesses. However, the effects of early life stress and adult stress on addictive behaviors have not been sufficiently investigated. We examined the effects of early life stress in the form of prolonged maternal separation followed in early adulthood by either 10 days of chronic variable stress or no stress on methamphetamine self-administration, extinction, and cue-induced reinstatement. We observed that chronic variable stress in adulthood reduced methamphetamine self-administration in rats with a history of early life stress. These findings add to an emerging body of literature suggesting interactions between and early life and early adulthood stressors on adult behavioral phenotypes.