PERSISTENCE OF SERUM ANTIBODIES TO BORRELIA-BURGDORFERI IN PATIENTS TREATED FOR LYME-DISEASE
PERSISTENCE OF SERUM ANTIBODIES TO BORRELIA-BURGDORFERI IN PATIENTS TREATED FOR LYME-DISEASE
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DOI：
10.1093/clind/15.5.788
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发表时间：
1992-11-01
影响因子：
11.8
通讯作者：
RYAN, RW
中科院分区：
文献类型：
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作者：
FEDER, HM;GERBER, MA;RYAN, RW
为了确定抗生素治疗后伯氏疏螺旋体抗体是否持续存在，我们从初级保健诊所召回了32名莱姆病患者，平均治疗后16个月，并用ELISA法和免疫印迹法分析了初始和随访的血清样本。8例首次血清标本检测为IgM抗体阳性的患者中，3例在随访时抗体滴度为阳性，23例首次血清标本检测为抗体阳性的患者中，19例在随访时抗体滴度为阳性。初次免疫印迹阳性的5例患者中，2例随访时IgM抗体滴度阳性，30例初次血清免疫印迹阳性的患者中，29例随访时抗体滴度阳性。从初始标本分析到后续标本分析期间，免疫印迹上的条带保持显著恒定。32名患者中有9名患者有持续或复发的症状，而ELISA法和免疫印迹法对识别这9名患者没有帮助。
To determine if antibodies to Borrelia burgdorferi persist after antibiotic treatment, we recalled 32 patients with Lyme disease from a primary care practice a mean of 16 months after treatment and analyzed initial and follow-up serum samples by ELISA and immunoblot assays. Of the eight patients whose initial serum specimens were positive for IgM antibody by ELISA, three had positive titers of IgM antibody at follow-up; of the 23 patients whose initial serum specimens were positive for IgG antibody by ELISA, 19 had positive titers of IgG at follow-up. Of the five patients whose initial serum specimens were positive for IgM antibody by immunoblot, two had positive titers of IgM antibody at follow-up; of the 30 patients whose initial serum specimens were positive for IgG antibody by immunoblot, 29 had positive titers of IgG antibody at follow-up. The bands on the IgG immunoblot remained remarkably constant during the period from analysis of the initial specimen to that of the follow-up specimen. Nine of the 32 patients had persistent or recurrent symptoms, and ELISA and immunoblot were not helpful for identifying these nine patients.