The effect of weight loss on sleep-disordered breathing and oxygen desaturation in morbidly obese men.
The effect of weight loss on sleep-disordered breathing and oxygen desaturation in morbidly obese men.
复制标题
减肥对病态肥胖男性睡眠呼吸障碍和氧饱和度降低的影响。
作者：
E. Harman;J. Wynne;A. Block
四名病态肥胖男性在平均体重减轻108公斤（53-155公斤）后，被发现有明显的睡眠呼吸障碍和氧饱和度降低。在所有的研究对象中，体重减轻的同时，每小时睡眠呼吸障碍事件的发作次数也显著减少。在四名受试者中，有三名受试者的去饱和程度随呼吸异常有所改善。两名在减肥前伴有白天嗜睡和高碳酸血症的受试者在去饱和性方面表现出最显著的改善。这表明肥胖是睡眠呼吸暂停综合症的原因，而不是结果。
Four morbidly obese men who had been found to have significant sleep-disordered breathing and oxygen desaturation were restudied after an average weight loss of 108 kg (range 53-155 kg). In all subjects, weight loss was accompanied by a significant reduction in the number of episodes per hour of sleep-disordered breathing events. In three of the four subjects, there was improvment in the severity of desaturation accompanying abnormal breathing. The two subjects with daytime somnolence and hypercapnia prior to weight loss showed the most dramatic improvement in desaturation. This suggests that obesity is a cause, rather than an effect, of the sleep apnea syndrome.