Innate immunity against malaria parasites in Anopheles gambiae
Innate immunity against malaria parasites in Anopheles gambiae
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DOI：
10.1111/j.1744-7917.2008.00186.x
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发表时间：
2008-02-01
期刊：
影响因子：
4
通讯作者：
Zheng, Liangbiao
中科院分区：
文献类型：
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作者：
Chen, Yang;Weng, Zhi-Hui;Zheng, Liangbiao
疟疾继续在当今世界造成巨大的死亡，每年造成约4亿病例，并造成1-2百万人死亡。非洲国家承担了大部分疟疾负担。出于这个原因，人们正在对该大陆疟疾的主要传播媒介冈比亚按蚊进行深入研究。随着这一重要媒介的序列草案的完成，正在努力开发新的控制策略。一个有希望的领域是利用这种蚊子的先天免疫力来阻止疟疾寄生虫的传播。最近的研究表明，Toll和Imd信号通路和其他免疫相关基因（编码蛋白质可能在识别或作为效应分子）在两个不同的先天免疫臂中发挥重要作用：感染强度和疟原虫卵囊的黑化水平。未来的挑战是了解这些不同基因的功能如何协调以抵御疟疾寄生虫，以及先天免疫的不同分支是否交叉调节或协调。
Malaria continues to exert a huge toll in the world today, causing approximately 400 million cases and killing between 1-2 million people annually. Most of the malaria burden is borne by countries in Africa. For this reason, the major vector for malaria in this continent, Anopheles gambiae, is under intense study. With the completion of the draft sequence of this important vector, efforts are underway to develop novel control strategies. One promising area is to harness the power of the innate immunity of this mosquito species to block the transmission of the malaria parasites. Recent studies have demonstrated that Toll and Imd signaling pathways and other immunity-related genes (encoding proteins possibly function in recognition or as effector molecules) play significant roles in two different arms of innate immunity: level of infection intensity and melanization of Plasmodium oocysts. The challenges in the future are to understand how the functions of these different genes are coordinated in defense against malaria parasites, and if different arms of innate immunity are cross-regulated or coordinated.