De novo asymmetric syntheses of muricatacin and its analogues via dihydroxylation of dienoates.
De novo asymmetric syntheses of muricatacin and its analogues via dihydroxylation of dienoates.
复制标题
通过二烯酸酯的二羟基化从头不对称合成 muricatacin 及其类似物。
DOI：
10.1021/jo061057s
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发表时间：
2006
期刊：
影响因子：
--
通讯作者：
O'Doherty,GeorgeA
中科院分区：
文献类型：
--
作者：
Ahmed,MdMoinuddin;Cui,Hu;O'Doherty,GeorgeA
A short and highly efficient route to both enantiomers of muricatacin as well as the C-5-epimer has been developed. The key to the overall transformation is the highly regio- and enantioselective Sharpless asymmetric dihydroxylation of an (E,Z)-dienoate. The highly efficient stereoselective synthesis prepares (−)-muricatacin in seven steps and 66% overall yield.
