TGF-β Signaling in Lung Health and Disease.
TGF-β Signaling in Lung Health and Disease.
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DOI：
10.3390/ijms19082460
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发表时间：
2018-08-20
影响因子：
5.6
通讯作者：
Nagase T
中科院分区：
文献类型：
--
作者：
Saito A;Horie M;Nagase T
转化生长因子 (TGF)-β 是一种进化上保守的多效性因子，可调节多种生物过程，包括发育、组织再生、免疫反应和肿瘤发生。基因工程小鼠模型证明，TGF-β 对于肺器官发生和稳态是必需的。 TGF-β 对于肺分支形态发生和肺泡化过程中的上皮间质相互作用至关重要。肺中三种 TGF-β 配体亚型的表达和激活在时间和空间上受到多种机制的调节。肺部在结构上暴露于外在刺激和病原体，并且容易发生炎症、过敏反应和致癌。在主要肺部疾病中观察到 TGF-β 配体的上调，包括肺纤维化、肺气肿、支气管哮喘和肺癌。 TGF-β 调节多种细胞过程，例如上皮细胞生长抑制、肺泡上皮细胞分化、成纤维细胞活化和细胞外基质组织。这些效应与肺纤维化和肺气肿的组织重塑密切相关。 TGF-β 也是 T 细胞稳态的核心，并与哮喘气道炎症密切相关。 TGF-β是非小细胞肺癌细胞中最有效的上皮-间质转化诱导剂，对于肺癌组织中促肿瘤微环境的发展至关重要。本综述总结并整合了与肺部健康和疾病相关的 TGF-β 信号传导的当前知识。
Transforming growth factor (TGF)-β is an evolutionarily conserved pleiotropic factor that regulates a myriad of biological processes including development, tissue regeneration, immune responses, and tumorigenesis. TGF-β is necessary for lung organogenesis and homeostasis as evidenced by genetically engineered mouse models. TGF-β is crucial for epithelial-mesenchymal interactions during lung branching morphogenesis and alveolarization. Expression and activation of the three TGF-β ligand isoforms in the lungs are temporally and spatially regulated by multiple mechanisms. The lungs are structurally exposed to extrinsic stimuli and pathogens, and are susceptible to inflammation, allergic reactions, and carcinogenesis. Upregulation of TGF-β ligands is observed in major pulmonary diseases, including pulmonary fibrosis, emphysema, bronchial asthma, and lung cancer. TGF-β regulates multiple cellular processes such as growth suppression of epithelial cells, alveolar epithelial cell differentiation, fibroblast activation, and extracellular matrix organization. These effects are closely associated with tissue remodeling in pulmonary fibrosis and emphysema. TGF-β is also central to T cell homeostasis and is deeply involved in asthmatic airway inflammation. TGF-β is the most potent inducer of epithelial-mesenchymal transition in non-small cell lung cancer cells and is pivotal to the development of tumor-promoting microenvironment in the lung cancer tissue. This review summarizes and integrates the current knowledge of TGF-β signaling relevant to lung health and disease.
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影响因子：
64.8
作者：
Bettelli, E;Carrier, YJ;Kuchroo, VK
通讯作者：
Kuchroo, VK
DOI：
10.1152/ajplung.00298.2004
发表时间：
2005-04-01
影响因子：
4.9
作者：
Chen, H;Sun, JP;Shi, W
通讯作者：
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影响因子：
4.4
作者：
Bonniaud, P;Kolb, M;Gauldie, J
通讯作者：
Gauldie, J
影响因子：
4.8
作者：
Ebisawa, T;Fukuchi, M;Miyazono, K
通讯作者：
Miyazono, K
DOI：
10.1073/pnas.88.15.6642
发表时间：
1991-08-01
影响因子：
11.1
作者：
BROEKELMANN, TJ;LIMPER, AH;MCDONALD, JA
通讯作者：
MCDONALD, JA