Alcohol intake in adolescence and mammographic density.
Alcohol intake in adolescence and mammographic density.
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青春期的酒精摄入量和乳房X光密度。
DOI：
10.1002/ijc.21227
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发表时间：
2005
影响因子：
6.4
通讯作者：
Cerhan,JamesR
中科院分区：
文献类型：
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作者：
Vachon,CelineM;Sellers,ThomasA;Janney,CarolA;Brandt,KathleenR;Carlson,ErinE;Pankratz,VernonS;Wu,Fang-Fang;Therneau,TerryM;Cerhan,JamesR
青少年接触可能对以后患乳腺癌很重要。我们研究了青少年饮酒与成人乳腺摄影密度的关系，这是乳腺癌的一个强风险因素。明尼苏达州乳腺癌家族队列中的女性，详细的乳房X光检查和风险因素信息（n= 1，893）形成了我们的样本。排除乳腺癌病例。青少年饮酒（18岁之前）是通过邮寄问卷征求。使用计算机辅助阈值程序Cumulus估计密度百分比（PD）。使用线性混合效应模型进行统计分析。报告在18岁之前饮酒的女性（n= 390; 21%）比青春期从未饮酒的女性（μ unadj= 26.5% vs. 22.2%）具有更高的未经调整的PD，但随着对乳房X线摄影密度风险因素的调整，这种差异消失（μ adj= 21.0% vs. 21.2%，p= 0.94）。成人PD与开始时的年龄、一次饮酒量或18岁之前饮酒的频率无关。在绝经状态分层中观察到缺乏差异。有建议更高的PD之间的沉重和更频繁的饮酒者（24.0%，95% CI 21.1-26.8%）与较轻的（21.3%，95% CI 20.3-22.3%）和从不饮酒者（21.4%，95% CI 20.9-21.9%），并且在每天或每周饮酒的成年人中也是如此。（25.0%，95% CI 23.0-27.0%），与这2个时间段内不常饮酒者（23.0-23.4%）相比。然而，这些相关性在统计学上并不显著（分别为p= 0.27和p= 0.22）。总之，没有证据表明青少年饮酒与成人PD的大而持久的影响相关。© 2005 Wiley利斯，Inc.
Adolescent exposures may be important in the development of breast cancer later in life. We examined the association of adolescent alcohol consumption and adult mammographic density, a strong risk factor for breast cancer. Women within the Minnesota Breast Cancer Family Cohort with detailed mammogram and risk factor information (n= 1,893) formed our sample. Breast cancer cases were excluded. Adolescent alcohol consumption (before age 18) was solicited through a mailed questionnaire. Percent density (PD) was estimated using the computer‐assisted thresholding program, Cumulus. Statistical analyses were performed using linear mixed effect models. Women who reported ever drinking alcohol before age 18 (n= 390; 21%) had a higher unadjusted PD than women who never drank during adolescence (̂μ unadj= 26.5% vs. 22.2%), but this difference disappeared with adjustment for risk factors for mammographic density (̂μ adj= 21.0% vs. 21.2%, p= 0.94). Adult PD was not associated with age at initiation, amount of alcohol consumed at one sitting or frequency of alcohol use before age 18. The lack of differences was seen across strata of menopausal status. There was suggestion of higher PD among heavy and more frequent drinkers (24.0%, 95% CI 21.1–26.8%) compared to lighter (21.3%, 95% CI 20.3–22.3%) and never drinkers (21.4%, 95% CI 20.9–21.9%) and also among regular adolescent drinkers who were daily or weekly adult drinkers (25.0%, 95% CI 23.0–27.0%) compared to less regular drinkers in these 2 time periods (23.0–23.4%). However, these associations were not statistically significant (p= 0.27 and p= 0.22, respectively). In summary, there was no evidence that adolescent alcohol use was associated with large and persistent effects on adult PD.© 2005 Wiley‐Liss, Inc.