Chromatin Compaction in Noncompaction Cardiomyopathy.
Chromatin Compaction in Noncompaction Cardiomyopathy.
复制标题
非致密化心肌病中的染色质致密化。
DOI：
10.1161/circresaha.123.323015
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发表时间：
2023
影响因子：
20.1
通讯作者：
Trivedi,ChinmayM
中科院分区：
文献类型：
--
作者：
Cashman,TimothyJ;Trivedi,ChinmayM
Noncompaction cardiomyopathy (NCM) is among a recently recognized cardiomyopathy with a distinct spongy appearance to the myocardial wall. It was first described in 19841 in the context of congenital heart disease and not recognized as an independent form of cardiomyopathy for another 50 years until Chin et al2 first reported a cohort of isolated NCM. The characteristic feature of NCM is heart failure, with imaging studies demonstrating a 2-layered ventricular wall with a thin outer layer of compact myocardium and a deep, sponge-like inner layer of trabecular myocardium. While the left ventricle is the most predominant form, the right ventricle is increasingly understood to have a similar role. However, despite advanced imaging techniques, it is still challenging to differentiate normal left ventricular trabeculation versus NCM or the relationship of trabeculation in other more common forms of cardiomyopathies, including dilated and hypertrophic. As a result, the reported prevalence of NCM varies considerably across studies, likely reflecting heterogeneous populations, inconsistent clinical criteria, and diagnostic challenges in imaging. Indeed, less than half of NCM cases are felt to be genetic, with the remaining half sporadic or with no clear mutation. 3
影响因子：
11.8
作者：
Stankunas, Kryn;Hang, Calvin T.;Chang, Ching-Pin
通讯作者：
Chang, Ching-Pin
影响因子：
3.5
作者：
Lewandowski, Sara L.;Janardhan, Harish P.;Trivedi, Chinmay M.
通讯作者：
Trivedi, Chinmay M.
持续性心肌血窦的超声心动图检测[J].
DOI：
--
发表时间：
1984
期刊：
Zeitschrift für Kardiologie
影响因子：
--
作者：
R. Engberding;F. Bender
通讯作者：
F. Bender