Shear stress and atherosclerosis.
Shear stress and atherosclerosis.
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DOI：
10.14348/molcells.2014.0078
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发表时间：
2014-06
影响因子：
3.8
通讯作者：
Abe J
中科院分区：
文献类型：
--
作者：
Heo KS;Fujiwara K;Abe J
血流动力学切应力是作用于血管内皮细胞的摩擦力，在正常生理条件下对内皮细胞的动态平衡至关重要。当讨论血流对各种形式的内皮(Dys)功能的影响时，人们考虑两种流动模式：稳定的层流和扰动流动，因为在体内和体外，内皮细胞对这些流动类型的反应是不同的。层流施加稳定的层流剪应力是动脉粥样硬化的保护作用，而扰动流动则创造了动脉粥样硬化的环境。新的证据为血管功能的血流依赖性调节的细胞机制提供了新的见解，这些血管功能导致动脉粥样硬化、动脉粥样硬化血栓形成和心肌梗死等心血管事件。为了研究剪切力和不同类型流动的影响，人们使用了各种模型。在这篇综述中，我们将总结我们目前的观点，即紊乱的血流介导的信号通路如何参与动脉粥样硬化的发展。
Hemodynamic shear stress, the frictional force acting on vascular endothelial cells, is crucial for endothelial homeostasis under normal physiological conditions. When discussing blood flow effects on various forms of endothelial (dys)function, one considers two flow patterns: steady laminar flow and disturbed flow because endothelial cells respond differently to these flow types both in vivo and in vitro. Laminar flow which exerts steady laminar shear stress is atheroprotective while disturbed flow creates an atheroprone environment. Emerging evidence has provided new insights into the cellular mechanisms of flow-dependent regulation of vascular function that leads to cardiovascular events such as atherosclerosis, atherothrombosis, and myocardial infarction. In order to study effects of shear stress and different types of flow, various models have been used. In this review, we will summarize our current views on how disturbed flow-mediated signaling pathways are involved in the development of atherosclerosis.