Age-related differences in fat-free mass, skeletal muscle, body cell mass and fat mass between 18 and 94 years
Age-related differences in fat-free mass, skeletal muscle, body cell mass and fat mass between 18 and 94 years
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DOI：
10.1038/sj.ejcn.1601198
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发表时间：
2001-08-01
影响因子：
4.7
通讯作者：
Pichard, C
中科院分区：
文献类型：
--
作者：
Kyle, UG;Genton, L;Pichard, C
目的：确定(1)18 ~ 94岁健康体力活动者中以无脂质量（FFM）、阑尾骨骼肌质量（ASMM）、体细胞质量（BCM）、全身钾（TBK）、脂肪质量和百分比脂肪质量反映的瘦体区室和脂肪区室及其在年龄组间的差异；(2)与其他参数相比，任何一个参数随年龄的下降速度是否可能加快。方法：采用双能x线吸收仪（DXA）和全身闪烁计数器（TBK计数器）对433例18-94岁的健康流动白种人（男253例，女180例）进行测量，采用大碘化钠晶体（203 ram直径）。结果：与18 - 34岁受试者相比，75岁左右受试者的ASMM变化（男性和女性分别为- 16.4%和-12.3%）大于FFM变化（男性和女性分别为- 11.8%和-9.7%），这表明老年受试者的骨骼肌质量下降比例大于非骨骼肌质量。BCM（男性和女性分别为- 25.1%和-23.2%）和TBK的差异大于FFM或ASMM的差异，这表明老年受试者FFM的组成发生了变化。女性FFM、ASMM、BCM和TBK的峰值均低于男性。结论：60岁以后男性和女性FFM、ASMM、BCM和TBK的下降速度加快，FFM、ASMM、BCM和TBK明显低于年轻受试者。脂肪量持续增加，直到75岁左右。赞助：瑞士日内瓦基金会营养2000Plus。
Objective: To determine (1) lean and fat body compartments, reflected by fat-free mass (FFM), appendicular skeletal muscle mass (ASMM), body cell mass (BCM), total body potassium (TBK), fat mass and percentage fat mass, and their differences between age groups in healthy, physically active subjects from 18 to 94 y of age; and (2) if the rate of decrease in any one of the parameters by age might be accelerated compared to others.Methods: A total of 433 healthy ambulatory Caucasians (253 men and 180 women) aged 18-94y were measured by dual-energy X-ray absorptiometry (DXA) and whole body scintillation counter (TBK counter) using a large sodium iodide crystal (203 ram diameter).Results: The ASMM change (-16.4 and -12.3% in men and women, respectively) in > 75 y-old compared to 18 to 34-y-old subjects was greater than the FFM change (-11.8 and -9.7% in men and women, respectively) and this suggests that skeletal muscle mass decrease in older subjects was proportionally greater than non-skeletal muscle mass. BCM (-25.1 and -23.2% in men and women, respectively) and TBK differences were greater than the differences in FFM or ASMM suggesting altered composition of FFM in older subjects. Women had lower peak FFM, ASMM, BCM and TBK than men.Conclusions: The decline in FFM, ASMM, BCM and TBK is accelerated in men and women after 60 y of age and FFM, ASMM, BCM and TBK are significantly lower than in younger subjects. Fat mass continued to increase until around 75 y.Sponsorship: Foundation Nutrition 2000Plus, Geneva, Switzerland.