Estrogen alters c-Fos response to immobilization stress in the brain of ovariectomized rats
Estrogen alters c-Fos response to immobilization stress in the brain of ovariectomized rats
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DOI：
10.1016/j.brainres.2006.02.008
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发表时间：
2006-04-21
期刊：
影响因子：
2.9
通讯作者：
Tsuruo, Yoshihiro
中科院分区：
文献类型：
--
作者：
Ueyama, Takashi;Tanioku, Tadashi;Tsuruo, Yoshihiro
雌激素受体在大脑中广泛表达，雌激素在大脑中调节中枢神经功能。在这项研究中，我们通过比较接受安慰剂治疗（OVX + Pla）的卵巢切除大鼠与补充 17 β-雌二醇（OVX + E2）的卵巢切除大鼠对固定应激（IMO）的 c-Fos 表达响应的中枢神经系统模式，研究雌激素对大脑情绪应激反应的影响。根据之前的研究结果，在大脑皮层、隔膜、丘脑、下丘脑、中脑、脑桥和延髓中观察到响应 IMO 的 c-Fos 免疫反应性神经元增加。 OVX+E2/Stress与OVX+Pla/Stress相比，外侧隔、下丘脑室旁核、下丘脑背内侧核、内侧杏仁核、外侧导水管周围灰质、背侧被盖核和蓝斑的c-Fos免疫反应细胞数量明显减少，而丘脑室旁核和孤立核的c-Fos免疫反应细胞数量明显增多。道。这些数据表明这些区域的神经元活动受到全身雌激素水平的双向影响。 (c) 2006 Elsevier B.V. 保留所有权利。
Estrogen receptors are widely expressed in the brain, where estrogen modulates central nervous function. In this study, we investigated the effect of estrogen on the emotional stress response in the brain by comparing the CNS patterns of c-Fos expression in response to immobilization stress (IMO) in ovariectomized rats with placebo treatment (OVX + Pla) vs. ovariectomized rats supplemented with 17 beta-estradiol (OVX + E2). Increased c-Fos immunoreactive neurons in response to IMO were observed in cerebral cortex, septum, thalamus, hypothalamus, midbrain, pons and medulla oblongata in accordance with previous findings. When OVX + E2/Stress were compared with OVX + Pla/Stress, the numbers of c-Fos immunoreactive cells were significantly lower in the lateral septum, paraventricular hypothalamic nucleus, dorsomedial hypothalamic nucleus, medial amygdaloid nucleus, lateral periaqueductal gray, laterodorsal tegmental nucleus and locus coeruleus, while they were significantly higher in paraventricular thalamic nucleus and nucleus of the solitary tract. These data suggest that neuronal activities in these areas are influenced bidirectionally by systemic estrogen level. (c) 2006 Elsevier B.V. All rights reserved.