25- to 30-nm virus particle associated with a hospital outbreak of acute gastroenteritis with evidence for airborne transmission.
25- to 30-nm virus particle associated with a hospital outbreak of acute gastroenteritis with evidence for airborne transmission.
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25 至 30 nm 病毒颗粒与医院爆发的急性胃肠炎有关，有空气传播的证据。
DOI：
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发表时间：
1988
影响因子：
5
通讯作者：
D. Low
中科院分区：
文献类型：
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作者：
L. Sawyer;L. Sawyer;J. J. Murphy;J. Kaplan;P. Pinsky;Daniela Chacon;S. Walmsley;L. Schonberger;A. Phillips;K. Forward;C. Goldman;J. Brunton;J. Brunton;R. Fralick;Anne O. Carter;W. Gary;R. Glass;D. Low;D. Low
1985年11月1日至22日，加拿大安大略多伦多一家拥有600张床位的医院爆发了急性非细菌性胃肠炎。2，379名工作人员中有635名（27%）的疾病表现为疲劳、恶心、腹泻和呕吐，中位持续时间为24-48小时。在6份粪便标本中发现25-30 nm的病毒样颗粒，对诺瓦克病毒（3/39）和雪山因子（1/6）的血清应答率较低，表明诺瓦克样病毒是此次暴发的原因。疫情突发、高发，单日影响79人。未发现常见的食物或水暴露。在急诊室工作的工作人员的攻击率最高（69%）。在11月11日至12日因无关问题前往急诊室的100名患者及其同伴中，33名（33%）在就诊后24-48小时发生胃肠炎，而11月8日前往急诊室的18名患者中0名（p <0.001）。对11月9日至13日期间至少工作过一次的管家进行的分析，包括那些在11月9日至14日期间生病的人，显示那些访问或走过急诊室的人生病的风险是那些没有的人的四倍（p = 0.028）。这些数据与病毒通过空气传播的可能性相一致。
Between November 1 and 22, 1985, an outbreak of acute, nonbacterial gastroenteritis occurred in a 600-bed hospital in Toronto, Ontario, Canada. Illness in 635 of 2,379 (27%) staff was characterized by fatigue, nausea, diarrhea, and vomiting and had a median duration of 24-48 hours. The finding of virus-like particles measuring 25-30 nm in six stool specimens and low rates of seroresponse to Norwalk virus (3/39) and Snow Mountain agent (1/6) suggest that a Norwalk-like virus was responsible for the outbreak. The outbreak was of abrupt onset and high incidence, affecting 79 people in a single day. No common food or water exposure could be identified. The attack rate was greatest (69%) for staff who had worked in the Emergency Room. Of 100 patients and their companions who visited the Emergency Room on November 11-12 for unrelated problems, 33 (33%) developed gastroenteritis 24-48 hours after their visit, versus 0 of 18 who visited the Emergency Room on November 8 (p less than 0.001). An analysis of housekeepers who worked at least once during the period from November 9-13, which included those who became ill during the period of November 9-14, showed that the risk of becoming ill was four times greater for those who visited or walked through the Emergency Room than for those who did not (p = 0.028). These data are consistent with the possibility of the airborne spread of a virus.