Chromosome 5p Region SNPs Are Associated with Risk of NSCLC among Women.
Chromosome 5p Region SNPs Are Associated with Risk of NSCLC among Women.
复制标题
染色体 5p 区域 SNP 与女性患 NSCLC 的风险相关。
DOI：
10.1155/2009/242151
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发表时间：
2009
影响因子：
1.8
通讯作者：
Schwartz,AnnG
中科院分区：
文献类型：
--
作者：
VanDyke,AlisonL;Cote,MicheleL;Wenzlaff,AngelaS;Abrams,Judith;Land,Susan;Iyer,Priyanka;Schwartz,AnnG
在一项基于人群的病例对照研究中，我们探讨了该区域7个基因的42个多态性与高加索人（364例; 380例对照）和非洲裔美国人（95例; 103例对照）女性非小细胞肺癌（NSCLC）风险之间的相关性。两个TERT-region SNPs，rs 2075786和rs 2853677，增加了NSCLC的发病风险，尤其是在非裔美国女性中，TERT-rs 2735940与非裔美国人肺癌风险降低相关。20个GHR多态性中的5个和SEPP 1-rs6413428与高加索人中NSCLC风险的轻微增加相关。随机森林分析加强了GHR在高加索人中的重要性，并确定了AMACR，TERT和GHR在非洲裔美国人中的重要性，这些因素在基于基因的风险评分中也很重要。研究了吸烟-SNP相互作用，并确定了与NSCLC风险相关的TERT和GHR单倍型。TERT、GHR、AMAC和SEPP 1基因在肺癌发生中的作用有待进一步研究。
In a population‐based case‐control study, we explored the associations between 42 polymorphisms in seven genes in this region and non‐small cell lung cancer (NSCLC) risk among Caucasian (364 cases; 380 controls) and African American (95 cases; 103 controls) women. TwoTERTregion SNPs, rs2075786 and rs2853677, conferred an increased risk of developing NSCLC, especially among African American women, andTERT‐rs2735940 was associated with a decreased risk of lung cancer among African Americans. Five of the 20GHRpolymorphisms andSEPP1‐rs6413428 were associated with a marginally increased risk of NSCLC among Caucasians. Random forest analysis reinforced the importance ofGHRamong Caucasians and identifiedAMACR, TERT, andGHRamong African Americans, which were also significant using gene‐based risk scores. Smoking‐SNP interactions were explored, and haplotypes inTERTandGHRassociated with NSCLC risk were identified. The roles ofTERT, GHR, AMACRandSEPP1genes in lung carcinogenesis warrant further exploration.