Signals regulating adhesion dynamics.
Signals regulating adhesion dynamics.
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调节粘附动力学的信号。
DOI：
10.1155/2012/785196
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发表时间：
2012
期刊：
影响因子：
--
通讯作者：
DeMali,KrisA
中科院分区：
文献类型：
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作者：
Webb,DonnaJ;Brown,ClaireM;DeMali,KrisA
粘附是细胞之间（细胞-细胞）以及细胞与细胞外基质（细胞-ECM）之间的接触部位，其对于许多生物过程如胚胎发生、伤口愈合和免疫应答是必不可少的。它们由许多不同的分子组成，包括粘附受体、信号蛋白（例如激酶、磷酸酶和衔接蛋白）和结构蛋白（例如肌动蛋白结合蛋白）[1-3]。粘附是动态结构，其分子组成和结构可以经历快速变化，以允许细胞对外部信号做出响应[1，4]。事实上，细胞局部区域内粘附的这种动态性质对于许多复杂过程（如细胞迁移）至关重要。对于细胞-ECM粘附，它们的组装通过整合素粘附受体与ECM的结合而启动。这些新的粘附可以分解，允许细胞迁移，或者通过将信号和结构蛋白募集到这些位点来继续成熟。粘附的动力学和组成由信号网络控制，该信号网络的功能是整合来自细胞内外的分子信号。这期特刊聚焦于调节粘附动力学的分子信号，重点是细胞-ECM粘附。整合素是跨膜粘附受体，在ECM和肌动蛋白细胞骨架之间提供功能性联系。ECM的整合素接合用于将信号传递到调节细胞行为的细胞内部。RGD依赖性整合素是特异性识别RGD基序的粘附受体的亚组，所述RGD基序是在一些ECM蛋白中发现的三个氨基酸序列（Arg-Gly-Asp）。在这期特刊中，YD Benoit等回顾了最近关于RGD依赖性整合素在上皮细胞稳态中的重要性的研究结果。
Adhesions are sites of contact between cells (cell-cell) and between cells and the extracellular matrix (cell-ECM) that are essential for numerous biological processes such as embryogenesis, wound healing, and the immune response. They are composed of many different molecules including adhesion receptors, signaling proteins (eg, kinases, phosphatases, and adaptor proteins), and structural proteins (eg, actin-binding proteins)[1–3]. Adhesions are dynamic structures whose molecular composition and structure can undergo rapid changes to allow cells to respond to external signals [1, 4]. Indeed, this dynamic nature of adhesions within localized regions of cells is critical for many complex processes such as cell migration. For cell-ECM adhesions, their assembly is initiated by the binding of integrin adhesion receptors to the ECM. These new adhesions can either disassemble, allowing cells to migrate, or continue to mature by recruiting signaling and structural proteins to these sites. The dynamics and composition of adhesions are controlled by signaling networks that function to integrate molecular signals from outside and within cells. This special issue focuses on the molecular signals that regulate adhesion dynamics with an emphasis on cell-ECM adhesions.Integrins are transmembrane adhesion receptors that provide a functional link between the ECM and the actin cytoskeleton. Integrin engagement of the ECM serves to transduce signals to the interior of cells which regulate cell behavior. RGD-dependent integrins are a subgroup of adhesion receptors that specifically recognize the RGD motif, which is a three-amino-acid sequence (Arg-Gly-Asp) that is found in some ECM proteins. In this special issue, YD Benoit et al. review recent findings regarding the importance of RGD-dependent integrins in epithelial cell homeostasis.