Severe somatization in women is associated with altered cerebral glucose metabolism
Severe somatization in women is associated with altered cerebral glucose metabolism
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DOI：
10.1017/s0033291702006578
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发表时间：
2002-11-01
影响因子：
6.9
通讯作者：
Niemi, P
中科院分区：
文献类型：
--
作者：
Hakala, M;Karlsson, H;Niemi, P
背景资料。躯体化是一种临床现象，以多种医学上无法解释的躯体症状为特征。其病理生理机制尚不清楚。我们的目的是在这种疾病的病理生理学中验证中枢神经系统功能障碍的假说。根据DSM-IV，我们研究了10名女性患者，诊断为躯体化障碍或未分化的躯体形式障碍，目前没有轴I障碍。并与17名健康女性志愿者进行脑部[18F]-氟代脱氧葡萄糖-正电子发射计算机断层扫描(MRI)对比。脑葡萄糖代谢率较低(P<0.05)。
Background. Somatization is a clinical phenomenon characterized by multiple, medically unexplained somatic symptoms. The pathophysiology remains unknown. We aimed to test the hypothesis of a central nervous system dysfunction in the pathophysiology of this disorder.Method. We studied 10 female patients diagnosed as having somatization disorder or undifferentiated somatoform disorder with no current Axis I disorders according to DSM-IV. They were compared with 17 healthy female volunteers using brain [18F]-fluorodeoxyglucose-PET with MRI reference.Results. The patients had lower cerebral metabolism rates of glucose (P