SRC-1 and TIF2 control energy balance between white and brown adipose tissues
SRC-1 and TIF2 control energy balance between white and brown adipose tissues
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DOI：
10.1016/s0092-8674(02)01169-8
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发表时间：
2002-12-27
期刊：
影响因子：
64.5
通讯作者：
Auwerx, J
中科院分区：
文献类型：
--
作者：
Picard, F;Géhin, M;Auwerx, J
我们探讨了 p160 核心调节器家族的两个成员对能量稳态的影响。 TIF2-/- 小鼠可以预防肥胖，并表现出增强的适应性生热作用，而 SRC-1-/- 小鼠由于能量消耗减少而容易肥胖。在白色脂肪组织中，TIF2的缺乏会降低PPARγ活性并减少脂肪积累，而在棕色脂肪组织中，它促进SRC-1和PGC-1α之间的相互作用，从而诱导PGC-1α的生热活性。有趣的是，高脂肪饮食会增加 TIF2/SRC-1 的表达比率，这可能会导致体重增加。这些结果表明TIF2/SRC-1的相对水平可以调节能量代谢。
We have explored the effects of two members of the p160 coregulator family on energy homeostasis. TIF2-/- mice are protected against obesity and display enhanced adaptive thermogenesis, whereas SRC-1-/- mice are prone to obesity due to reduced energy expenditure. In white adipose tissue, lack of TIF2 decreases PPARgamma activity and reduces fat accumulation, whereas in brown adipose tissue it facilitates the interaction between SRC-1 and PGC-1alpha, which induces PGC-1alpha's thermogenic activity. Interestingly, a high-fat diet increases the TIF2/SRC-1 expression ratio, which may contribute to weight gain. These results reveal that the relative level of TIF2/SRC-1 can modulate energy metabolism.