Comparative Analysis of Salivary Mycobiome Diversity in Human Immunodeficiency Virus-Infected Patients.
Comparative Analysis of Salivary Mycobiome Diversity in Human Immunodeficiency Virus-Infected Patients.
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人类免疫缺陷病毒感染患者唾液分枝菌组多样性的比较分析
DOI：
10.3389/fcimb.2021.781246
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发表时间：
2021
影响因子：
5.7
通讯作者：
Du M
中科院分区：
文献类型：
--
作者：
Chang S;Guo H;Li J;Ji Y;Jiang H;Ruan L;Du M
关于HIV感染患者口腔真菌组改变的报告仍然有限。本研究旨在比较30例人类免疫缺陷病毒（HIV）感染者和30例健康对照者的唾液真菌群，并探讨抗逆转录病毒治疗（ART）对HIV感染者口腔真菌群的影响。结果表明，HIV感染者唾液真菌群落的多样性和丰富度均高于对照组（P < 0.05）。ART治疗后，HIV感染者唾液真菌菌群的多样性和丰富度明显降低（P < 0.05）。HIV组念珠菌属、被孢霉属、马拉色菌属、单纯菌属和青霉属的相对丰度显著增加，ART后显著降低，而轮枝菌属、伊萨琴菌属和链格孢属的相对丰度在ART后显著增加。相关分析显示，被孢霉属、马拉色菌属、单纯菌属和毛壳菌属与病毒载量（VL）呈正相关，甲状腺基质菌和古根菌与VL呈负相关，与CD4+ T细胞计数呈正相关。所有结果表明，HIV感染和ART管理影响唾液真菌群落的组成。此外，ART后HIV感染者唾液真菌群的差异是复杂的，可能反映了机体的免疫状态。
Reports on alterations in the oral mycobiome of HIV-infected patients are still limited. This study was designed to compare the salivary mycobiome between 30 human immunodeficiency virus (HIV) infections and 30 healthy controls and explore the effect of antiretroviral therapy (ART) administration on the oral mycobiome of HIV infections. Results showed that the diversity and richness of salivary mycobiome in HIV-infected individuals were higher than those of controls (P < 0.05). After ART, the diversity and richness of salivary mycobiome in HIV-infected patients were reduced significantly (P < 0.05). Candida, Mortierella, Malassezia, Simplicillium, and Penicillium were significantly enriched in the HIV group and dramatically decreased after ART. While the relative abundance of Verticillium, Issatchenkia, and Alternaria significantly increased in patients with HIV after ART. Correlation analysis revealed that Mortierella, Malassezia, Simplicillium, and Chaetomium were positively correlated with viral load (VL), whereas Thyrostroma and Archaeorhizomyces were negatively related to VL and positively related to CD4+ T-cell counts. All results showed that HIV infection and ART administration affected the composition of salivary mycobiome communities. Furthermore, differences of salivary mycobiome in HIV infections after ART were complex and might mirror the immune state of the body.