Developmental trajectories in early hematopoiesis
Developmental trajectories in early hematopoiesis
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DOI：
10.1101/gad.1861709
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发表时间：
2009-10-15
影响因子：
10.5
通讯作者：
Murre, Cornelis
中科院分区：
文献类型：
--
作者：
Murre, Cornelis
一段时间以来，造血干细胞从多能、自我更新的细胞发育成定型淋巴细胞的路径一直是争论的话题。在早期造血过程中，已描述了多个分支点，其中子代细胞分离成具有不同发育潜力的细胞谱系。在本期《基因与发育》中，Inlay 及其同事（第 2376-2381 页）确定了造血祖细胞移动的新中间阶段。
The paths that hematopoietic stem cells take to develop from multipotent, self-renewing cells into committed lymphocytes has been a topic of debate for some time. During early hematopoiesis, multiple branchpoints have been described in which progeny cells segregate into cell lineages with distinct developmental potentials. In this issue of Genes & Development, Inlay and colleagues (pp. 2376-2381) identify novel intermediate stages through which hematopoietic progenitor cells travel.