Effect of type of early infant feeding on fatty acid composition of plasma lipid classes in full-term infants during the second 6 months of life
Effect of type of early infant feeding on fatty acid composition of plasma lipid classes in full-term infants during the second 6 months of life
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DOI：
10.1097/00005176-200005000-00015
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发表时间：
2000-05-01
影响因子：
2.9
通讯作者：
Kohn, G
中科院分区：
文献类型：
--
作者：
Decsi, T;Kelemen, B;Kohn, G
背景：此前，作者发现，母乳喂养的 2 个月大足月婴儿血浆脂质中的花生四烯酸和二十二碳六烯酸值显着高于配方奶粉喂养的婴儿。这是在足月婴儿出生后第一年下半年获得的数据报告。 方法：对喂养母乳 (n = 12) 或不含预先形成的长链多不饱和脂肪酸的配方奶粉 (n = 12) 的健康足月婴儿进行调查。通过高分辨率毛细管气相色谱法测定血浆脂质类别的脂肪酸组成。结果：血浆磷脂中的亚油酸值（18.5 [3.94] vs. 20.79 [4.34]）以及血浆胆固醇酯中的 γ-亚麻酸值（0.17 [0.09] vs. 0.27 [0.20]）和三酰甘油母乳喂养的婴儿（0.27 [0.18] vs. 0.46 [0.27]）显着（P < 0.05）低于配方奶粉喂养的婴儿。数据分别为母乳喂养婴儿与配方奶喂养婴儿的体重百分比，显示为中位数（范围从第一四分位数到第三四分位数）。相比之下，血浆磷脂中的花生四烯酸值（10.05 [2.90] vs. 7.03 [1.87]；P i 0.01）、胆固醇酯（7.54 [3.58] vs. 4.09 [1.81]；P < 0.05）和三酰甘油（1.28 [0.84] vs. 0.80） [0.39]；P i 0.05），以及血浆磷脂中的二十二碳六烯酸值（1.92 [0.36] vs. 1.02 [0.31]；P < 0.001）、胆固醇酯（0.39 [0.13] vs. 0.15 [0.13]；Pi 0.001）和三酰甘油（0.17 [0.17] vs. 0.09 [0.04]；P i 0.01）在母乳喂养的婴儿中显着高于配方奶粉喂养的婴儿。 结论：健康足月婴儿喂养不含预制膳食长链多不饱和脂肪酸的配方奶，即使在出生后第一年的后半段，也无法与母乳喂养婴儿的花生四烯酸和二十二碳六烯酸状态相匹配。 (C) 2000 Lippincott Williams & Wilkins, Inc.
Background: Previously, the authors found significantly higher arachidonic and docosahexaenoic acid values in plasma lipids in 2-month-old full-term infants fed human milk than in those receiving formula. This is the report of data obtained in full-term infants during the second half of the first year of life.Methods: Healthy, full-term infants fed human milk(n = 12) or formula without preformed long-chain polyunsaturated fatty acids (n = 12) were investigated. Fatty acid composition of plasma lipid classes was determined by high-resolution capillary gas-liquid chromatography.Results: Linoleic acid acid values in plasma phospholipids (18.5 [3.94] vs. 20.79 [4.34]) and gamma-linolenic acid values in plasma cholesteryl esters (0.17 [0.09] vs. 0.27 [0.20]) and triacylglycerols (0.27 [0.18] vs. 0.46 [0.27]) were significantly (P < 0.05) lower in breast-fed infants than in those receiving formula. Data are percentage weight by weight shown as median (range from Ist to 3rd quartile) for breast-fed vs. formula fed infants, respectively. In contrast, arachidonic acid values in plasma phospholipids (10.05 [2.90] vs. 7.03 [1.87]; P i 0.01), cholesteryl esters (7.54 [3.58] vs. 4.09 [1.81]; P < 0.05), and triacylglycerols (1.28 [0.84] vs. 0.80 [0.39]; P i 0.05), as well as docosahexaenoic acid values in plasma phospholipids (1.92 [0.36] vs. 1.02 [0.31]; P < 0.001), cholesteryl esters (0.39 [0.13] vs. 0.15 [0.13]; Pi 0.001), and triacylglycerols (0.17 [0.17] vs. 0.09 [0.04]; P i 0.01) were significantly higher in infants fed human milk than in those receiving formula.Conclusion: Healthy, full-term infants fed formula without preformed dietary long-chain polyunsaturated fatty acids are unable to match the arachidonic and docosahexaenoic acid status of breast-fed infants even during the second half of the first year of life. (C) 2000 Lippincott Williams & Wilkins, Inc.