Molecular epidemiology and restriction site mapping of adenovirus type 3 genome types
Molecular epidemiology and restriction site mapping of adenovirus type 3 genome types
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3 型腺病毒基因组类型的分子流行病学和限制性位点定位
DOI：
10.1128/jcm.27.6.1329-1334.1989
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发表时间：
1989
影响因子：
9.4
通讯作者：
R. Wigand
中科院分区：
文献类型：
--
作者：
T. Adrian;B. Best;J. Hierholzer;R. Wigand
1961年至1984年间，用6种限制性内切酶分析了从美国、西德国和其他地区的患者中分离的138株3型腺病毒，发现了18种基因组类型，BglII是最具鉴别力的酶。还对所有六种酶进行了改变的限制性位点的作图。基因组类型D1（如原型）和D3分别在45和47株菌株中占优势。所有基因组类型可分为与D1或D3相关的两组。观察到具有相同基因组类型的菌株的几个感染簇。在个体基因组类型的致病性中只发现了差异的迹象。D1菌株在美国和欧洲存在; D3组几乎仅在美国流行。
One hundred thirty-eight strains of adenovirus type 3 isolated from patients in the United States, West Germany, and other regions between 1961 and 1984 were analyzed with six restriction endonucleases; 18 genome types were found. BglII was the most discriminative enzyme. Mapping of altered restriction sites was also performed for all six enzymes. The genome types D1 (like the prototype) and D3 prevailed among 45 and 47 strains, respectively. All genome types could be divided into two groups related to D1 or D3. Several clusters of infections by strains with the same genome type were observed. Only hints of differences were found in the pathogenicities of individual genome types. D1 strains were present in the United States and in Europe; group D3 prevailed almost exclusively in the United States.