Unraveling the complex metabolic nature of astrocytes.
Unraveling the complex metabolic nature of astrocytes.
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DOI：
10.3389/fncel.2013.00179
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发表时间：
2013-10-11
影响因子：
5.3
通讯作者：
Pellerin L
中科院分区：
文献类型：
--
作者：
Bouzier-Sore AK;Pellerin L
Since the initial description of astrocytes by neuroanatomists of the nineteenth century, a critical metabolic role for these cells has been suggested in the central nervous system. Nonetheless, it took several technological and conceptual advances over many years before we could start to understand how they fulfill such a role. One of the important and early recognized metabolic function of astrocytes concerns the reuptake and recycling of the neurotransmitter glutamate. But the description of this initial property will be followed by several others including an implication in the supply of energetic substrates to neurons. Indeed, despite the fact that like most eukaryotic non-proliferative cells, astrocytes rely on oxidative metabolism for energy production, they exhibit a prominent aerobic glycolysis capacity. Moreover, this unusual metabolic feature was found to be modulated by glutamatergic activity constituting the initial step of the neurometabolic coupling mechanism. Several approaches, including biochemical measurements in cultured cells, genetic screening, dynamic cell imaging, nuclear magnetic resonance spectroscopy and mathematical modeling, have provided further insights into the intrinsic characteristics giving rise to these key features of astrocytes. This review will provide an account of the different results obtained over several decades that contributed to unravel the complex metabolic nature of astrocytes that make this cell type unique.
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影响因子：
4.7
作者：
Bouzier, AK;Thiaudiere, E;Merle, M
通讯作者：
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DOI：
10.3389/fnene.2011.00005
发表时间：
2011
期刊：
Frontiers in neuroenergetics
影响因子：
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作者：
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通讯作者：
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DOI：
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发表时间：
2003-11-01
影响因子：
6.3
作者：
Bouzier-Sore, AK;Voisin, P;Pellerin, T
通讯作者：
Pellerin, T
影响因子：
4.4
作者：
Bergersen, L;Rafiki, A;Ottersen, OP
通讯作者：
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DOI：
10.1523/jneurosci.2040-10.2010
发表时间：
2010-10-20
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
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通讯作者：
Rothman DL