Combined approach to counteract experimental cancer cachexia: eicosapentaenoic acid and training exercise
Combined approach to counteract experimental cancer cachexia: eicosapentaenoic acid and training exercise
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DOI：
10.1007/s13539-011-0028-4
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发表时间：
2011-06-01
影响因子：
8.9
通讯作者：
Argiles, Josep M.
中科院分区：
文献类型：
--
作者：
Penna, Fabio;Busquets, Silvia;Argiles, Josep M.
背景癌症恶病质是一种以骨骼肌蛋白质丢失、脂肪储备耗尽、食欲减退、虚弱和激素平衡紊乱为特征的综合征。方法：本研究旨在验证二十碳五烯酸(EPA)预防Lewis肺癌小鼠肌肉萎缩的能力，以及耐力运动训练提高EPA效果的能力。结果EPA单独应用不能预防肿瘤生长所致的肌肉丢失，而EPA与运动联合应用可部分恢复肌肉力量和质量。此外，EPA和运动的联合减少了PAX-7的显著积聚，并刺激了PCG-1蛋白的增加。结论综合而言，目前的数据表明，运动是治疗癌症恶病质的综合治疗方法中应该增加的有效工具。
Background Cancer cachexia is a syndrome characterized by loss of skeletal muscle protein, depletion of lipid stores, anorexia, weakness, and perturbations of the hormonal homeostasis. Despite several therapeutic approaches described in the past, effective interventions countering cancer cachexia are still lacking.Methods The present work was aimed to verify the ability of eicosapentaenoic acid (EPA) to prevent the muscle depletion in Lewis lung carcinoma-bearing mice and to test the ability of endurance exercise training to increase the EPA effect.Results EPA alone did not prevent the muscle loss induced by tumor growth while the combination with exercise induced a partial rescue of muscle strength and mass. Moreover, the association of EPA and exercise reduced the dramatic PAX-7 accumulation and stimulated the increase of PCG-1 protein.Conclusions Overall, the present data suggest that exercise is an effective tool that should be added for combined therapeutic approaches against cancer cachexia.