LEUKOARAIOSIS IN RELATION TO PROGNOSIS FOR PATIENTS WITH LACUNAR INFARCTION
LEUKOARAIOSIS IN RELATION TO PROGNOSIS FOR PATIENTS WITH LACUNAR INFARCTION
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DOI：
10.1161/01.str.23.10.1434
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发表时间：
1992-10-01
期刊：
影响因子：
8.3
通讯作者：
TAKAHASHI, A
中科院分区：
文献类型：
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作者：
MIYAO, S;TAKANO, A;TAKAHASHI, A
背景和目的：据报道，计算机断层扫描或磁共振成像检测到的脑白质疏松症与中风，特别是腔隙性脑梗塞之间存在密切关系。我们研究了脑白质疏松症是否与腔隙性脑梗死患者的长期预后有关。方法：我们每月检查215例首次卒中后的腔隙性脑梗死患者。他们包括95名入院时通过计算机断层扫描发现的脑白质疏松症患者（58名男性和37名女性;平均年龄，71.3 ± 9.0岁）和120名无脑白质疏松症患者（81名男性和39名女性;平均年龄，65.5 ± 8.9岁）。这些患者在发生中风之前没有中风或明显痴呆的病史。我们比较了预后与脑白质疏松症的基础上分析复发性中风，生存，痴呆的患病率和依赖率在日常生活activity.Results：生命表分析显示，脑白质疏松症患者的复发性中风率显着高于那些没有它（p=0.004）。脑白质疏松症患者痴呆的患病率和日常生活活动的依赖率在卒中后1个月和随访期结束时均显著较高（所有参数，p
Background and Purpose: Close relations between leukoaraiosis detected by computed tomography or magnetic resonance imaging and stroke, particularly lacunar infarction, have been reported. We studied whether leukoaraiosis is related to long-term prognosis for patients with lacunar infarction.Methods: We examined monthly 215 patients with lacunar infarction after their first stroke. They comprised 95 patients with leukoaraiosis disclosed by computed tomography on admission (58 men and 37 women; mean age, 71.3+/-9.0 years) and 120 patients without leukoaraiosis (81 men and 39 women; mean age, 65.5+/-8.9 years). These patients had no previous history of either stroke or obvious dementia before their index stroke. We compared the prognosis with and without leukoaraiosis based on analysis of recurrent stroke, survival, and the prevalence of dementia and rate of dependence in activities of daily living.Results: Life table analysis revealed that the recurrent stroke rate was significantly higher in the patients with leukoaraiosis than in those without it (p=0.004). The prevalence of dementia and rate of dependence in activities of daily living both 1 month after the index stroke and at the end of the follow-up period were significantly higher in the patients with leukoaraiosis (all parameters, p