Implications of Gut Microbiota in Neurodegenerative Diseases.
Implications of Gut Microbiota in Neurodegenerative Diseases.
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肠道微生物群对神经退行性疾病的影响
DOI：
10.3389/fimmu.2022.785644
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发表时间：
2022
影响因子：
7.3
通讯作者：
Cheng P
中科院分区：
文献类型：
--
作者：
Zhang H;Chen Y;Wang Z;Xie G;Liu M;Yuan B;Chai H;Wang W;Cheng P
与神经退行性疾病（ND）相关的发病率正在增加，对人类的精神和身体生活质量构成威胁。微生物群对大脑生理过程的关键作用是通过双向相互作用介导的，称为肠-脑轴（GBA），目前正在研究中。许多临床和实验室试验已经表明，微生物群通过各种微生物分子在ND的发展中的重要性，这些微生物分子通过GBA或神经系统从肠道传输到大脑。本文综述了肠道微生物群在ND中的意义，这将有助于了解ND的病因和进展，进而有助于制定ND干预措施和临床治疗方法。
The morbidity associated with neurodegenerative diseases (NDs) is increasing, posing a threat to the mental and physical quality of life of humans. The crucial effect of microbiota on brain physiological processes is mediated through a bidirectional interaction, termed as the gut–brain axis (GBA), which is being investigated in studies. Many clinical and laboratory trials have indicated the importance of microbiota in the development of NDs via various microbial molecules that transmit from the gut to the brain across the GBA or nervous system. In this review, we summarize the implications of gut microbiota in ND, which will be beneficial for understanding the etiology and progression of NDs that may in turn help in developing ND interventions and clinical treatments for these diseases.