Neurodevelopmental outcomes among 2- to 3-year-old children in Bangladesh with elevated blood lead and exposure to arsenic and manganese in drinking water.
Neurodevelopmental outcomes among 2- to 3-year-old children in Bangladesh with elevated blood lead and exposure to arsenic and manganese in drinking water.
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DOI：
10.1186/s12940-016-0127-y
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发表时间：
2016-03-12
期刊：
影响因子：
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通讯作者：
Mazumdar M
中科院分区：
文献类型：
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作者：
Rodrigues EG;Bellinger DC;Valeri L;Hasan MO;Quamruzzaman Q;Golam M;Kile ML;Christiani DC;Wright RO;Mazumdar M
孟加拉国人民目前接触到饮用水中高浓度的砷和锰，以及许多地区铅含量升高。这项研究的目的是调查环境暴露于这些污染物与孟加拉儿童神经发育结果之间的关系。我们评估了524名儿童的数据，他们是正在进行的预期出生队列的成员，该队列的建立是为了研究孟加拉国Sirajdikhan和Pabna地区产前和早期儿童砷暴露的影响。水是在怀孕前三个月以及1、12和20-40个月时从家庭主要饮用水来源收集的。在20-40个月大时，测量血铅，并使用翻译的、文化适应的贝利婴幼儿发育量表第三版(BSID-III)评估神经发育结果。锡拉迪汗的中位血铅浓度高于帕布纳(7.6vs.lt；LODμg/dL，p<；0.0001)，水砷浓度低于帕布纳(1.5vs25.7.μg/L，p<；0.0001)。在锡拉迪汗，血铅水平的升高与认知得分的下降有关(β =−为0.17，SE = 为0.09，p = 为0.05)，而水砷水平的升高与Pabna的认知得分下降有关(β =−为0.06，SE = 为0.03，p = 为0.05)。在Pabna中，水锰与精细运动评分呈反U关系。在血铅水平高的地方，铅与BSID-III的认知分数下降有关，其他金属的影响不被检测到。在铅水平较低的情况下，观察到砷和锰对神经发育的不利影响。本文的在线版本(doi：10.1186/s12940-0160127-y)包含补充材料，授权用户可以使用。
The people of Bangladesh are currently exposed to high concentrations of arsenic and manganese in drinking water, as well as elevated lead in many regions. The objective of this study was to investigate associations between environmental exposure to these contaminants and neurodevelopmental outcomes among Bangladeshi children. We evaluated data from 524 children, members of an ongoing prospective birth cohort established to study the effects of prenatal and early childhood arsenic exposure in the Sirajdikhan and Pabna Districts of Bangladesh. Water was collected from the family’s primary drinking source during the first trimester of pregnancy and at ages 1, 12 and 20–40 months. At age 20–40 months, blood lead was measured and neurodevelopmental outcomes were assessed using a translated, culturally-adapted version of the Bayley Scales of Infant and Toddler Development, Third Edition (BSID-III). Median blood lead concentrations were higher in Sirajdikhan than Pabna (7.6 vs. <LODμg/dL, p <0.0001) and water arsenic concentrations were lower (1.5 vs 25.7 μg/L, p <0.0001). Increased blood lead was associated with decreased cognitive scores in Sirajdikhan (β = −0.17, SE = 0.09, p = 0.05), whereas increased water arsenic was associated with decreased cognitive scores in Pabna (β = −0.06, SE = 0.03, p = 0.05). Water manganese was associated with fine motor scores in an inverse-U relationship in Pabna. Where blood lead levels are high, lead is associated with decreased cognitive scores on the BSID-III, and effects of other metals are not detected. In the setting of lower lead levels, the adverse effects of arsenic and manganese on neurodevelopment are observed. The online version of this article (doi:10.1186/s12940-016-0127-y) contains supplementary material, which is available to authorized users.