WONOEP APPRAISAL: The many facets of epilepsy networks
WONOEP APPRAISAL: The many facets of epilepsy networks
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DOI：
10.1111/epi.14503
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发表时间：
2018-08-01
期刊：
影响因子：
5.6
通讯作者：
de Curtis, Marco
中科院分区：
文献类型：
--
作者：
Scott, Rod C.;de la Prida, Liset Menendez;de Curtis, Marco
大脑是一个复杂的系统，由从基因到电路的相互作用的元素网络组成，其功能（和功能障碍）不能从单个组件的叠加中推导出来。癫痫通常被描述为一种网络疾病，但迄今为止，还没有标准化的框架，可在其中使用适用于从基因到全脑各个水平的网络概念来更深入地了解癫痫发作或相关疾病的发病机制。为了解决这一缺陷，国际抗癫痫联盟神经生物学委员会专门举办了癫痫神经生物学研讨会（XIV WONOEP 2017），旨在将网络概念正式化，因为它们适用于癫痫，并批判性地讨论这些概念是否以及如何增强当前的研究工作。在这里，我们回顾的概念和策略，认为癫痫作为一种疾病的不同网络层次，从基因到临床表型。我们认为网络的概念对于理解癫痫很重要，并且对于开发新的研究设计至关重要。这些方法最终可以促进新的诊断和治疗策略的发展。
The brain is a complex system composed of networks of interacting elements, from genes to circuits, whose function (and dysfunction) is not derivable from the superposition of individual components. Epilepsy is frequently described as a network disease, but to date, there is no standardized framework within which network concepts applicable to all levels from genes to whole brain can be used to generate deeper insights into the pathogenesis of seizures or the associated morbidities. To address this shortcoming, the Neurobiology Commission of the International League Against Epilepsy dedicated a Workshop on Neurobiology of Epilepsy (XIV WONOEP 2017) with the aim of formalizing network concepts as they apply to epilepsy and to critically discuss whether and how such concepts could augment current research endeavors. Here, we review concepts and strategies derived by considering epilepsy as a disease of different network hierarchies that range from genes to clinical phenotypes. We propose that the concept of networks is important for understanding epilepsy and is critical for developing new study designs. These approaches could ultimately facilitate the development of novel diagnostic and therapeutic strategies.