A single brain-derived neurotrophic factor injection modifies hypothalamo-pituitary-adrenocortical axis activity in adult male rats
A single brain-derived neurotrophic factor injection modifies hypothalamo-pituitary-adrenocortical axis activity in adult male rats
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DOI：
10.1016/j.mcn.2004.07.002
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发表时间：
2004-11-01
影响因子：
3.5
通讯作者：
Tapia-Arancibia, L
中科院分区：
文献类型：
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作者：
Givalois, L;Naert, G;Tapia-Arancibia, L
制动应激诱导成年雄性大鼠下丘脑室旁核（PVN）脑源性神经营养因子（BDNF）表达的快速激活先于促肾上腺皮质激素释放激素（CRH）和垂体后叶素-加压素（AVP）表达的增加。BDNF mRNA信号与CRH和AVP mRNA信号在PVN中迟来共定位，如原位杂交所确定的。在非麻醉成年雄性大鼠脑室内注射BDNF（5 μ g/大鼠）诱导CRH mRNA信号逐渐增加，而AVP mRNA信号在小细胞和大细胞PVN部分逐渐减少。同时，下丘脑CRH含量减少，AVP含量增加。这些变化伴随着ACTH和皮质酮血浆浓度的增加。这些结果强烈表明，脑源性神经营养因子可能是一种应激反应性细胞间信使，因为当外源性给予它时，它是下丘脑CRH和AVP神经元激活和募集的重要早期成分。(C)2004年爱思唯尔公司All rights reserved.
Immobilization stress induces in adult male rats rapid activation of brain derived neurotrophic factor (BDNF) expression in the hypothalamic paraventricular nucleus (PVN) preceding the increases in corticotropin releasing hormone (CRH) and arginin-vasopressin (AVP) expression. The BDNF mRNA signal belatedly co-localizes with CRH and AVP mRNA signals in the PVN, as determined by in situ hybridization. Intracerebroventricular BDNF injections (5 mug/rat) in non-anesthetized adult male rats induce a gradual increase in the CRH mRNA signal whereas AVP mRNA signal progressively decreases in the parvocellular and magnocellular PVN portions. At the same time, the CRH hypothalamic content decreases while the AVP content increases. These variations are accompanied by increases in ACTH and corticosterone plasma concentrations. These results strongly suggest that BDNF could be a stress-responsive intercellular messenger since when it is exogenously administered acts as an important and early component in the activation and recruitment of hypothalamic CRH and AVP neurons. (C) 2004 Elsevier Inc. All rights reserved.