Ultrahigh speed en face OCT capsule for endoscopic imaging
Ultrahigh speed en face OCT capsule for endoscopic imaging
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DOI：
10.1364/boe.6.001146
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发表时间：
2015-04-01
影响因子：
3.4
通讯作者：
Fujimoto, James G.
中科院分区：
文献类型：
--
作者：
Liang, Kaicheng;Traverso, Giovanni;Fujimoto, James G.
在内窥镜检查中，深度分辨和面OCT活体可视化可能具有重要的临床应用。我们展示了一个高速，二维（2D）的远端扫描胶囊与快速旋转扫描和精确的纵向扫描气动致动器的微电机。通过气动扫描仪的光学跟踪进行纵向位置测量和图像配准。2D扫描设备能够在小视场内实现高分辨率成像，并且适用于OCT以及其他扫描显微镜。用于筛查或监视应用的大视场成像也可以通过在扫描远端高速微电机的同时向近端拉回或推进胶囊来实现。使用MEMS可调谐VCSEL光源在1300 nm处以250 Hz帧速率和1 MHz A扫描速率在活体猪中证明了周向正面OCT。使用精确远端气动纵向驱动以及近端手动纵向驱动生成上消化道和下消化道的横截面和正面OCT视图。这些器械可以作为内窥镜检查的辅助器械，连接到内窥镜上，或作为吞咽栓系胶囊用于非内窥镜成像而无需镇静，从而实现临床研究。高速成像和远端扫描胶囊技术的结合可以实现筛查和监视应用。(C)2015年美国光学学会
Depth resolved and en face OCT visualization in vivo may have important clinical applications in endoscopy. We demonstrate a high speed, two-dimensional (2D) distal scanning capsule with a micromotor for fast rotary scanning and a pneumatic actuator for precision longitudinal scanning. Longitudinal position measurement and image registration were performed by optical tracking of the pneumatic scanner. The 2D scanning device enables high resolution imaging over a small field of view and is suitable for OCT as well as other scanning microscopies. Large field of view imaging for screening or surveillance applications can also be achieved by proximally pulling back or advancing the capsule while scanning the distal high-speed micromotor. Circumferential en face OCT was demonstrated in living swine at 250 Hz frame rate and 1 MHz A-scan rate using a MEMS tunable VCSEL light source at 1300 nm. Crosssectional and en face OCT views of the upper and lower gastrointestinal tract were generated with precision distal pneumatic longitudinal actuation as well as proximal manual longitudinal actuation. These devices could enable clinical studies either as an adjunct to endoscopy, attached to an endoscope, or as a swallowed tethered capsule for non-endoscopic imaging without sedation. The combination of ultrahigh speed imaging and distal scanning capsule technology could enable both screening and surveillance applications. (C) 2015 Optical Society of America