Synthesis and biological evaluation of aminopolyamines.
Synthesis and biological evaluation of aminopolyamines.
复制标题
氨基多胺的合成和生物学评价。
DOI：
10.1021/jm050024m
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发表时间：
2005
期刊：
影响因子：
--
通讯作者：
Nguyen,JohnNhut
中科院分区：
文献类型：
--
作者：
Bergeron,RaymondJ;Huang,Guangfei;McManis,JamesS;Yao,Hua;Nguyen,JohnNhut
Exploitation of the polyamine backbone as a vector for intracellular transport of various pharmacophores has focused largely on fixing the cargo molecule to one of the nitrogens in the linear chain. This communication describes the assembly of a model aminopolyamine analogue, 6-amino-N,N12-diethylspermine, and its biological properties. This amino polyamine presents an additional site of attachment for cargo molecules, reduces cell growth, and achieves cellular concentrations that are higher than those ofN1,N12-diethylspermine.
